Date published: 2026-4-4

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Tris(2-aminoethyl)amine (CAS 4097-89-6)

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Alternate Names:
TAEA
CAS Number:
4097-89-6
Molecular Weight:
146.23
Molecular Formula:
C6H18N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tris(2-aminoethyl)amine exhibits a zwitterionic nature, possessing both positive and negative charges. This compound is frequently employed in the investigation of biochemical and physiological processes, serving as a buffer to stabilize pH levels and maintain osmotic pressure. Moreover, Tris(2-aminoethyl)amine finds utility in protein purification, contributing to the preservation of enzyme and protein activity. In addition to these applications, it plays a role in the study of nucleic acids and the preparation of cell culture media.


Tris(2-aminoethyl)amine (CAS 4097-89-6) References

  1. Supramolecular chemistry of amine--phenol adducts; novel three-dimensional framework structures in adducts of bis(2-aminoethyl)amine with 4,4'-sulfonyldiphenol, 1,1,1-tris(4-hydroxyphenyl)-ethane and 3,5-dihydroxybenzoic acid, and in the methanol-solvated adduct of tris(2-aminoethyl)-amine with 4,4'-biphenol.  |  Glidewell, C., et al. 2000. Acta Crystallogr B. 56 (Pt 1): 68-84. PMID: 10735445
  2. Assembly of Carbohydrates on a Nickel(II) Center by Utilizing N-Glycosidic Bond Formation with Tris(2-aminoethyl)amine (tren). Syntheses and Characterization of [Ni{N-(aldosyl)-tren}(H(2)O)](2+), [Ni{N,N'-bis(aldosyl)-tren}](2+) and [Ni{N,N',N'-tris(aldosyl)-tren}](2+).  |  Tanase, T., et al. 1996. Inorg Chem. 35: 4848-4857. PMID: 11666684
  3. Structure/activity study of tris(2-aminoethyl)amine-derived translocases for phosphatidylcholine.  |  Boon, JM., et al. 2002. J Org Chem. 67: 2168-74. PMID: 11925224
  4. TREN (Tris(2-aminoethyl)amine): an effective scaffold for the assembly of triple helical collagen mimetic structures.  |  Kwak, J., et al. 2002. J Am Chem Soc. 124: 14085-91. PMID: 12440907
  5. Tris(2-aminoethyl) amine functionalized silica gel for solid-phase extraction and preconcentration of Cr(III), Cd(II) and Pb(II) from waters.  |  Huang, X., et al. 2008. J Hazard Mater. 157: 154-60. PMID: 18295398
  6. Star-shaped azomethines based on tris(2-aminoethyl)amine. Characterization, thermal and optical study.  |  Iwan, A., et al. 2010. Spectrochim Acta A Mol Biomol Spectrosc. 75: 891-900. PMID: 20036614
  7. Controllable assembly of dimers and trimers of gold Nanoparticle bridged by Tris(2-aminoethyl)amine.  |  Zhang, Z., et al. 2011. J Nanosci Nanotechnol. 11: 2163-7. PMID: 21449364
  8. Tris(2-aminoethyl)amine-based α-branched fatty acid amides - Synthesis of lipids and comparative study of transfection efficiency of their lipid formulations.  |  Erdmann, N., et al. 2015. Eur J Pharm Biopharm. 96: 349-62. PMID: 26325061
  9. Synthesis and characterization of new microgel from tris(2-aminoethyl)amine and glycerol diglycidyl ether as poly(TAEA-co-GDE).  |  urRehman, S., et al. 2015. Colloids Surf B Biointerfaces. 136: 1156-65. PMID: 26613866
  10. Structure, Spectra, and DFT Simulation of Nickel Benzazolate Complexes with Tris(2-aminoethyl)amine Ligand.  |  Cerezo, J., et al. 2017. Inorg Chem. 56: 3663-3673. PMID: 28252288
  11. High-Relaxivity Gd(III)-Hemicryptophane Complex.  |  Godart, E., et al. 2019. Org Lett. 21: 1999-2003. PMID: 30855968
  12. The influence of linkages between 1-hydroxy-2(1H)-pyridinone coordinating groups and a tris(2-aminoethyl)amine core in a novel series of synthetic hexadentate iron(III) chelators on antimicrobial activity.  |  Workman, DG., et al. 2020. Bioorg Chem. 95: 103465. PMID: 31855824
  13. Tris-(2-aminoethyl)amine-Intercalated Graphene Oxide as an Efficient 2D Material for Cerium-Ion Fluorescent Sensor Applications.  |  Elsie, S., et al. 2019. ACS Omega. 4: 22431-22437. PMID: 31909325
  14. Highly Branched Tannin-Tris(2-aminoethyl)amine-Urea Wood Adhesives.  |  Zhang, B., et al. 2023. Polymers (Basel). 15: PMID: 36850174
  15. A tris(2-aminoethyl)amine-based zinc complex as a highly water-soluble drug carrier for the anti-COVID-19 drug favipiravir: a joint experimental and theoretical study.  |  Hajibabaei, F., et al. 2023. Dalton Trans. 52: 7031-7047. PMID: 36880337

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tris(2-aminoethyl)amine, 25 g

sc-253785
25 g
$112.00

Tris(2-aminoethyl)amine, 100 g

sc-253785A
100 g
$233.00