Triptorelin (CAS 57773-63-4)
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Triptorelin, acting as a potent agonist of the Gonadotropin-Releasing Hormone Receptor (GnRHR), plays a role in the modulation of endocrine functions through its unique mechanism of action. By engaging with this receptor, Triptorelin effectively interrupts the natural hormonal signaling pathways, leading to a significant reduction in the production of certain hormones, such as estradiol. This mechanism is particularly important in the context of scientific investigations into the role of peptide hormones in various biological processes. Research utilizing Triptorelin has been instrumental in elucidating the complex interactions between hormonal regulation and cell proliferation, especially concerning its ability to inhibit estradiol-induced proliferation in certain cancer cell models. These studies contribute to a deeper understanding of the biochemical and physiological landscapes shaped by peptide hormones, offering valuable insights into the intricate mechanisms governing cellular behavior and hormone-driven diseases.
Triptorelin (CAS 57773-63-4) References
- Stability of triptorelin in the presence of dermis and epidermis. | Bachhav, YG. and Kalia, YN. 2009. Int J Pharm. 378: 149-51. PMID: 19486932
- Quantitation of slow release triptorelin in beagle dog plasma by liquid chromatography-tandem mass spectrometry. | Han, J., et al. 2012. J Pharm Biomed Anal. 66: 334-8. PMID: 22444328
- Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer. | Romero, E., et al. 2012. J Pharmacol Exp Ther. 342: 788-98. PMID: 22691297
- Triptorelin in the management of prostate cancer. | Ploussard, G. and Mongiat-Artus, P. 2013. Future Oncol. 9: 93-102. PMID: 23252566
- An analytical strategy to characterize the pharmacokinetics and pharmacodynamics of triptorelin in rats based on simultaneous LC-MS/MS analysis of triptorelin and endogenous testosterone in rat plasma. | Han, J., et al. 2014. Anal Bioanal Chem. 406: 2457-65. PMID: 24510211
- An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer. | Merseburger, AS. and Hupe, MC. 2016. Adv Ther. 33: 1072-93. PMID: 27246172
- Pulmonary Delivery of Triptorelin Loaded in Pluronic Based Nanomicelles in Rat Model. | Vakilzadeh, H., et al. 2018. Curr Drug Deliv. 15: 630-640. PMID: 29424314
- Investigation of adhesive interactions in the specific targeting of Triptorelin-conjugated PEG-coated magnetite nanoparticles to breast cancer cells. | Hu, J., et al. 2018. Acta Biomater. 71: 363-378. PMID: 29458110
- Micro-solid phase extraction and LC-MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study. | Ren, T., et al. 2019. J Pharm Biomed Anal. 166: 13-19. PMID: 30599277
- Effects of fixed-time artificial insemination using triptorelin on the reproductive performance of pigs: a meta-analysis. | Wang, Z., et al. 2020. Animal. 14: 1481-1492. PMID: 31858952
- Environmentally Friendly SPPS II: Scope of Green Fmoc Removal Protocol Using NaOH and Its Application for Synthesis of Commercial Drug Triptorelin. | Přibylka, A., et al. 2020. J Org Chem. 85: 8798-8811. PMID: 32519543
- Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI. | Yousefvand, M., et al. 2021. Contrast Media Mol Imaging. 2021: 5534848. PMID: 34104122
- Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF. | Jiang, XL., et al. 2022. Aging (Albany NY). 14: 8321-8345. PMID: 36309912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triptorelin, 10 mg | sc-396102 | 10 mg | $241.00 |