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Tripelennamine hydrochloride (CAS 154-69-8)

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Alternate Names:
2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride
CAS Number:
154-69-8
Molecular Weight:
291.82
Molecular Formula:
C16H21N3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tripelennamine hydrochloride functions by binding to and inhibiting histamine H1 receptors, which are crucial for the transmission of signals related to allergic responses. By blocking these receptors, tripelennamine hydrochloride prevents histamine from triggering its usual effects. This interaction effectively modulates the signaling pathways that histamine typically activates, controlling the physiological reactions associated with these pathways. This inhibition plays a key role in managing the cascade of reactions that histamine can initiate. As a result, the overall activity of histamine is reduced, leading to a decrease in the typical responses associated with its release. The effectiveness of tripelennamine hydrochloride in this role makes it a subject of interest for further exploration into how chemical signals can be regulated to manage and study various physiological processes.


Tripelennamine hydrochloride (CAS 154-69-8) References

  1. The effect of tripelennamine hydrochloride on visual acuity, color perception and stereoptic perception as evaluated by the ortho-rater.  |  KUTSCHER, AH., et al. 1954. Int Rec Med Gen Pract Clin. 167: 159-63. PMID: 13142710
  2. Antazoline hydrochloride, tripelennamine hydrochloride and locomotor activity.  |  BAIRD, JA. and BOYD, EM. 1954. J Pharm Pharmacol. 6: 398-402. PMID: 13184415
  3. A note on tripelennamine hydrochloride and locomotor activity.  |  BOYD, EM. and BOYD, MA. 1957. J Pharm Pharmacol. 9: 118-9. PMID: 13406719
  4. Tripelennamine hydrochloride and chlorprophenpyridamine maleate; a comparison of their efficacies in the treatment of hay fever.  |  BANCROFT, CM. 1957. Ann Allergy. 15: 297-304. PMID: 13445058
  5. The role of histamine in drug-induced eosinopenia and the blocking effects of tripelennamine hydrochloride.  |  ZARATZIAN, VL. 1959. Toxicol Appl Pharmacol. 1: 628-37. PMID: 13847036
  6. A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms.  |  MACLAREN, WR., et al. 1955. Ann Allergy. 13: 307-12. PMID: 14377226
  7. The effect of tripelennamine hydrochloride (pyribenzamine) on the release of histamine during in vitro hemolytic reaction in rabbit blood.  |  CARRYER, HM. and CODE, CF. 1950. J Allergy. 21: 314-7. PMID: 15428185
  8. Effect of tripelennamine hydrochloride on acute inflammation.  |  WEEKS, RE. and GUNNAR, RM. 1949. Arch Pathol (Chic). 48: 178-82. PMID: 18147090
  9. Effect of tripelennamine hydrochloride on burn shock.  |  GUNNAR, RM. and WEEKS, RE. 1949. Arch Pathol (Chic). 47: 594-7. PMID: 18150645
  10. The effect of tripelennamine hydrochloride on the gastric acidity of patients with peptic ulcer.  |  HARTMAN, SA. and MOORE, DM. 1948. Am J Dig Dis. 15: 271-5. PMID: 18873458
  11. Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions.  |  FISCHEL, EE. 1947. Proc Soc Exp Biol Med. 66: 537-41. PMID: 18900017
  12. Trace determination of the antihistamines tripelennamine hydrochloride, thenyldiamine hydrochloride, and chlorothen citrate in admixture in animal feed, human urine, and wastewater by high-pressure liquid chromatography and use of a fluorescence detector.  |  Thompson, HC., et al. 1983. Talanta. 30: 251-60. PMID: 18963353
  13. HPLC method for identification and quantification of three active substances in a dermatological preparation--Viosept ointment.  |  Podolska, M., et al. 2014. Acta Pol Pharm. 71: 709-19. PMID: 25362799
  14. Abuse of pentazocine-naloxone combination.  |  Reed, DA. and Schnoll, SH. 1986. JAMA. 256: 2562-4. PMID: 3773159
  15. Sustained release from inert wax matrixes II: effect of surfactants on tripelennamine hydrochloride release.  |  Dakkuri, A., et al. 1978. J Pharm Sci. 67: 354-7. PMID: 641722

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tripelennamine hydrochloride, 25 g

sc-229608
25 g
$78.00