TRIML1 Antibody (S-42): sc-100883

TRIML1 Antibody (S-42) is a mouse monoclonal IgG2b kappa light chain antibody that detects TRIML1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TRIML1 antibody (S-42) is available as a non-conjugated format. TRIML1 protein, also known as RNF209, is a 468 amino acid protein characterized by the presence of one SPRY domain and one RING-type zinc finger motif, which is crucial for function in the ubiquitination pathway. This pathway is essential for regulating protein degradation, thereby maintaining cellular homeostasis and responding to stress signals. The RING-type zinc finger motif allows TRIML1 to interact with E3 ubiquitin ligases, facilitating the transfer of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. This process is vital for controlling various cellular processes, including cell cycle progression, apoptosis, and immune responses. TRIML1 (S-42) antibody enables researchers to gain insights into TRIML1′s role in these critical biological functions and potential implications in diseases associated with dysregulated protein degradation.

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TRIML1 Antibody (S-42) References:

1. Protein fold analysis of the B30.2-like domain.  |  Seto, MH., et al. 1999. Proteins. 35: 235-49. PMID: 10223295
2. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.  |  Lorick, KL., et al. 1999. Proc Natl Acad Sci U S A. 96: 11364-9. PMID: 10500182
3. Structural and functional insights into the B30.2/SPRY domain.  |  Woo, JS., et al. 2006. EMBO J. 25: 1353-63. PMID: 16498413
4. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.  |  Borden, KL., et al. 1995. EMBO J. 14: 1532-41. PMID: 7729428
5. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRIML1 Antibody (S-42) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TRIML1 Antibody (S-42) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRIML1 Antibody (S-42) Specifications

Alternate Product Name: TRIML1

Product Clone Name: S-42

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 369-469

Epitope Target: TRIML1

Epitope Species: human

Product Reactivity/Detection: TRIML1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TRIML1 Antibody (S-42): N/A