Molecular structure of Trimidox, CAS Number: 95933-74-7
Trimidox (CAS 95933-74-7)
Alternate Names:
N, 3, 4, 5- tetrahydroxy- benzenecarboximidamide; VF 233
Application:
Trimidox is a specific ribonucleotide reductase inhibitor
CAS Number:
95933-74-7
Molecular Weight:
184.2
Molecular Formula:
C7H8N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.1
Trimidox (CAS 95933-74-7) References
1 Szekeres, T., Fritizer, M., Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12) 4316-4321 (1994). 2 Kanno, S., Uwai, K., Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic & Clinical Pharmacology & Toxicology 98 44-50 (2006).Inhibitor of:
R1 and R2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trimidox, 5 mg | sc-222372 | 5 mg | $98.00 | |||
Trimidox, 10 mg | sc-222372A | 10 mg | $187.00 |