Molecular structure of Trimethylarsinoxide, CAS Number: 4964-14-1
Trimethylarsinoxide (CAS 4964-14-1)
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Alternate Names:
Trimethylarsine oxide
Application:
Trimethylarsinoxide is a lipid soluble organic derivative of arsine
CAS Number:
4964-14-1
Molecular Weight:
136.02
Molecular Formula:
C3H9AsO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trimethylarsine oxide (TMAO) has found usage in diverse scientific applications, including the synthesis of other organoarsenic compounds and as a model compound for studying the biochemical and physiological impacts of arsenic. Furthermore, it has been utilized in research to explore its potential environmental toxicity. The precise mechanism of action of Trimethylarsine oxide is still somewhat indistinct. Nevertheless, it′s believed to be tied to its capability to interact with thiol-containing proteins, leading to the disruption of cellular processes. Additionally, Trimethylarsinoxide has been demonstrated to inhibit the activity of several enzymes, including cytochrome P450 enzymes, which are integral to the metabolism of many compounds.
Trimethylarsinoxide (CAS 4964-14-1) References
- Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism. | Nishikawa, T., et al. 2002. Int J Cancer. 100: 136-9. PMID: 12115560
- Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferation. | Shen, J., et al. 2003. Carcinogenesis. 24: 1827-35. PMID: 12919961
- Dimethylarsine and trimethylarsine are potent genotoxins in vitro. | Andrewes, P., et al. 2003. Chem Res Toxicol. 16: 994-1003. PMID: 12924927
- Speciation of dimethylarsinous acid and trimethylarsine oxide in urine from rats fed with dimethylarsinic acid and dimercaptopropane sulfonate. | Lu, X., et al. 2003. Anal Chem. 75: 6463-8. PMID: 14640715
- Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. | Waters, SB., et al. 2004. Chem Res Toxicol. 17: 1621-9. PMID: 15606138
- Toxicity and metabolism of trimethylarsine in mice and hamsters. | Yamauchi, H., et al. 1990. Fundam Appl Toxicol. 14: 399-407. PMID: 2318361
- Modulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice. | Elshenawy, OH. and El-Kadi, AO. 2015. Xenobiotica. 45: 930-43. PMID: 26042454
- Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies. | Elshenawy, OH. and El-Kadi, AO. 2015. Toxicol Lett. 238: 17-31. PMID: 26144063
- Elevated Trimethylarsine Oxide and Inorganic Arsenic in Northern Hemisphere Summer Monsoonal Wet Deposition. | Savage, L., et al. 2017. Environ Sci Technol. 51: 12210-12218. PMID: 28977751
- A unique arsenic speciation profile in Elaphomyces spp. ('deer truffles')-trimethylarsine oxide and methylarsonous acid as significant arsenic compounds. | Braeuer, S., et al. 2018. Anal Bioanal Chem. 410: 2283-2290. PMID: 29430602
- Cellular metabolism of arsenocholine. | Christakopoulos, A., et al. 1988. J Appl Toxicol. 8: 119-27. PMID: 3288685
- Trimethylarsine oxide in estuary catfish (Cnidoglanis macrocephalus) and school whiting (Sillago bassensis) after oral administration of sodium arsenate; and as a natural component of estuary catfish. | Edmonds, JS. and Francesconi, KA. 1987. Sci Total Environ. 64: 317-23. PMID: 3602996
- The reduction of trimethylarsine oxide by Candida humicola. | Pickett, AW., et al. 1981. Can J Microbiol. 27: 773-8. PMID: 7296411
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trimethylarsinoxide, 25 mg | sc-475468B | 25 mg | $325.00 | |||
Trimethylarsinoxide, 100 mg | sc-475468 | 100 mg | $560.00 | |||
Trimethylarsinoxide, 1 g | sc-475468A | 1 g | $3800.00 |