Trimethylamine-13C3 Hydrochloride (CAS 286013-00-1)

Trimethylamine-13C3 hydrochloride (TMA-13C3HCl) is a specially labeled compound used as a tracer in scientific investigations concerning the metabolism and physiological impact of trimethylamine (TMA). Trimethylamine-13C3 hydrochloridel serves as a vital tool in scientific research, allowing the exploration of TMA′s metabolic pathways in both animals and humans. This isotopically labeled compound is particularly valuable for studying the body′s absorption, distribution, metabolism, and excretion of TMA. When administered, Trimethylamine-13C3 Hydrochloride undergoes enzymatic transformation by monoamine oxidase (MAO), leading to the formation of trimethylamine N-oxide (TMAO). TMAO is subject to further enzymatic processes, primarily by aldehyde dehydrogenase (ALDH2) and cytochrome P450 (CYP450), resulting in the generation of various metabolites, including formaldehyde and formic acid.The metabolic journey continues as formic acid is subjected to additional enzymatic reactions, with lactate dehydrogenase (LDH) and aldehyde dehydrogenase (ALDH1) playing roles. Ultimately, these processes culminate in the excretion of these metabolites in urine. This compound, Trimethylamine-13C3 Hydrochloride, thus facilitates comprehensive investigations into the intricate pathways and impacts associated with TMA and its metabolic cascade.