Date published: 2025-10-19

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Trimethyl phosphate (CAS 512-56-1)

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Alternate Names:
TMP; TMPA; TMPO
CAS Number:
512-56-1
Purity:
97%
Molecular Weight:
140.07
Molecular Formula:
C3H9O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trimethyl phosphate (TMP) is an industrially and scientifically valuable organophosphate compound. This colorless liquid possesses a slightly sweet odor and exhibits solubility in organic solvents. With its versatility as a reagent, Trimethyl phosphate finds application in a broad spectrum of fields, including chemical synthesis, and biochemistry. It plays a role in synthesizing diverse organic and inorganic compounds and serves as a catalyst in polymer production. Scientific research has extensively utilized trimethyl phosphate in various domains, encompassing biochemical assays, and biocatalysis. It finds utility as a reactant in synthesizing peptides and proteins, as a catalyst in the creation of organic and inorganic compounds. Mechanistically, trimethyl phosphate acts as an inhibitor of enzymes catalyzing the hydrolysis of phosphorylated compounds.


Trimethyl phosphate (CAS 512-56-1) References

  1. Gas chromatography-mass spectrometry assay of the (18)o enrichment of water as trimethyl phosphate.  |  Brunengraber, DZ., et al. 2002. Anal Biochem. 306: 278-82. PMID: 12123666
  2. Adsorption of trimethyl phosphate on maghemite, hematite, and goethite nanoparticles.  |  Mäkie, P., et al. 2011. J Phys Chem A. 115: 8948-59. PMID: 21711003
  3. Adsorption of trimethyl phosphate and triethyl phosphate on dry and water pre-covered hematite, maghemite, and goethite nanoparticles.  |  Mäkie, P., et al. 2013. J Colloid Interface Sci. 392: 349-358. PMID: 23142013
  4. Polarizable Multipole-Based Force Field for Dimethyl and Trimethyl Phosphate.  |  Zhang, C., et al. 2015. J Chem Theory Comput. 11: 5326-39. PMID: 26574325
  5. Photooxidation of Trimethyl Phosphite in Nitrogen, Oxygen, and para-Hydrogen Matrixes at Low Temperatures.  |  Ramanathan, N., et al. 2017. J Phys Chem A. 121: 2121-2131. PMID: 28235181
  6. An All-Phosphate and Zero-Strain Sodium-Ion Battery Based on Na3V2(PO4)3 Cathode, NaTi2(PO4)3 Anode, and Trimethyl Phosphate Electrolyte with Intrinsic Safety and Long Lifespan.  |  Jiang, X., et al. 2017. ACS Appl Mater Interfaces. 9: 43733-43738. PMID: 29171750
  7. Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solid-phase microextraction.  |  Cai, C., et al. 2018. J Sep Sci. 41: 1104-1111. PMID: 29239108
  8. Towards Phosphate Detection in Hydroponics Using Molecularly Imprinted Polymer Sensors.  |  Storer, CS., et al. 2018. Sensors (Basel). 18: PMID: 29439386
  9. Efficient and Selective Adsorption of Gold Ions from Wastewater with Polyaniline Modified by Trimethyl Phosphate: Adsorption Mechanism and Application.  |  Wang, C., et al. 2019. Polymers (Basel). 11: PMID: 30970676
  10. Atomic Layer Deposition of Nitrogen-Doped Al Phosphate Coatings for Li-Ion Battery Applications.  |  Henderick, L., et al. 2020. ACS Appl Mater Interfaces. 12: 25949-25960. PMID: 32392406
  11. Anion Intercalation into a Graphite Electrode from Trimethyl Phosphate.  |  Zhang, L. and Wang, H. 2020. ACS Appl Mater Interfaces. 12: 47647-47654. PMID: 33030890
  12. Kinetics of the gas-phase reaction of hydroxyl radicals with trimethyl phosphate over the 273-837 K temperature range.  |  Koshlyakov, PV., et al. 2021. RSC Adv. 11: 14121-14131. PMID: 35423916
  13. UHPLC-MS/MS Method Development and Validation for the Genotoxic Impurities Trimethyl Phosphate and Triisopropyl Phosphate of Elagolix Sodium.  |  Hao, Y., et al. 2023. J Chromatogr Sci.. PMID: 37207323

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trimethyl phosphate, 250 g

sc-251353
250 g
$45.00