Date published: 2026-4-4

1-800-457-3801

SCBT Portrait Logo
Seach Input

Trimethyl orthoacetate (CAS 1445-45-0)

0.0(0)
Write a reviewAsk a question

CAS Number:
1445-45-0
Molecular Weight:
120.15
Molecular Formula:
C5H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Trimethyl orthoacetate is a clear liquid that readily dissolves in water, ethanol, and acetone. This compound serves multiple purposes, such as a solvent in the synthesis of organic compounds, preserving biological samples, and cryoprotectant biological tissues. Moreover, it′s used as an electrolyte in battery research. Reacting with alkanoic acids, trimethyl orthoacetate forms esters, which are important intermediates in the development of agrochemicals. The reaction mechanism of trimethyl orthoacetate has been studied by means of matrix effect and kinetic energy analysis, showing that it is an exothermic reaction.


Trimethyl orthoacetate (CAS 1445-45-0) References

  1. Kinetics and mechanisms of the homogeneous, unimolecular gas-phase elimination of trimethyl orthoacetate and trimethyl orthobutyrate.  |  Márquez, E., et al. 2008. J Phys Chem A. 112: 12140-2. PMID: 18973316
  2. Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation.  |  Sempere, Y. and Carreira, EM. 2018. Angew Chem Int Ed Engl. 57: 7654-7658. PMID: 29718576
  3. Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.  |  Garcia, P., et al. 2021. Drug Test Anal. 13: 1527-1534. PMID: 33870655
  4. A simple method for the determination of glyphosate, glufosinate and their metabolites in biological specimen by liquid chromatography/tandem mass spectrometry: an application for forensic toxicology.  |  Ohara, T., et al. 2021. Nagoya J Med Sci. 83: 567-587. PMID: 34552290
  5. Selective Esterification of Phosphonic Acids.  |  Trzepizur, D., et al. 2021. Molecules. 26: PMID: 34577108
  6. Detection and residence time of bisphosphonates in bone of horses.  |  Knych, HK., et al. 2022. J Vet Diagn Invest. 34: 23-27. PMID: 34918585
  7. Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.  |  Hollstein, S., et al. 2022. Angew Chem Int Ed Engl. 61: e202201831. PMID: 35384202
  8. Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.  |  Bizzarri, BM., et al. 2021. RSC Adv. 11: 30020-30029. PMID: 35480240
  9. 2-O-Acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids.  |  Sangiorgio, S., et al. 2022. Chirality. 34: 1038-1043. PMID: 35531652
  10. Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice.  |  Mao, Y., et al. 2022. J Enzyme Inhib Med Chem. 37: 2133-2146. PMID: 35920284
  11. Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain.  |  Artiukhov, AV., et al. 2022. Int J Mol Sci. 23: PMID: 36361974
  12. Multicomponent Synthesis of Diaminopurine and Guanine PNA's Analogues Active against Influenza A Virus from Prebiotic Compounds.  |  Bizzarri, BM., et al. 2022. ACS Omega. 7: 45253-45264. PMID: 36530301
  13. Methods and Strategies for Biomonitoring in Occupational Exposure to Plant Protection Products Containing Glyphosate.  |  Moldovan, H., et al. 2023. Int J Environ Res Public Health. 20: PMID: 36834010

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trimethyl orthoacetate, 100 ml

sc-251349
100 ml
$57.00