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Trimethoprim lactate salt (CAS 23256-42-0)

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Alternate Names:
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
Application:
Trimethoprim lactate salt is an antibacterial agent
CAS Number:
23256-42-0
Purity:
≥99%
Molecular Weight:
380.40
Molecular Formula:
C14H18N4O3•C3H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trimethoprim lactate, or trimethoprim lactate salt, is a potent antimicrobial agent widely used in laboratory applications for its antibacterial properties. Its versatility extends to multiple laboratory applications, including compound synthesis, bacterial infection detection, and antibiotic production. Scientific research benefits greatly from the diverse applications of trimethoprim lactate. It serves as a component in synthesizing a range of compounds like polymers and dyes. Furthermore, trimethoprim lactate has proven invaluable in studying the biochemical and physiological effects of various drugs and chemicals. The mode of action of trimethoprim lactate involves inhibiting the synthesis of dihydrofolate reductase, an essential enzyme in folic acid biosynthesis. Through this inhibition, trimethoprim lactate hinders the production of folic acid—a vital nutrient for bacterial growth. Additionally, it inhibits the production of thymidine, a necessary component for DNA replication.


Trimethoprim lactate salt (CAS 23256-42-0) References

  1. In vitro resistance of haemophilus influenzae to co-trimoxazole and trimethoprim.  |  Cornere, BM. and Menzies, R. 1975. N Z Med J. 81: 292-4. PMID: 1079587
  2. Isolation of mycobacteria from clinical specimens by use of selective 7H11 medium.  |  McClatchy, JK., et al. 1976. Am J Clin Pathol. 65: 412-5. PMID: 176886
  3. Inducible suicide vector systems for Trypanosoma cruzi.  |  Ma, Y., et al. 2015. Microbes Infect. 17: 440-50. PMID: 25899945
  4. Induction of Effective Immunity against Trypanosoma cruzi.  |  Williams, T., et al. 2020. Infect Immun. 88: PMID: 31907197
  5. Susceptibility of Branhamella catarrhalis to sulphamethoxazole and trimethoprim.  |  Riley, TV., et al. 1987. J Antimicrob Chemother. 19: 39-43. PMID: 3494008
  6. The selectivity of vancomycin and lincomycin in NYC medium for the recovery of N. gonorrhoeae from clinical specimens.  |  Faur, YC., et al. 1978. Health Lab Sci. 15: 22-7. PMID: 417048
  7. Variation in colonial morphology of Neisseria gonorrhoeae after growth on media containing antimicrobial agents.  |  James, AN., et al. 1973. Appl Microbiol. 26: 248-51. PMID: 4201640
  8. Joint trimethoprim and sulphamethoxazole resistance in bacteria infected with R factors.  |  Pinney, RJ. and Smith, JT. 1973. J Med Microbiol. 6: 13-9. PMID: 4570475
  9. Neisseria gonorrhoeae: colonial morphology of rectal isolates.  |  Kovalchik, MT. and Kraus, SJ. 1972. Appl Microbiol. 23: 986-9. PMID: 4624216
  10. A new medium for the isolation of pathogenic Neisseria (NYC medium). II. Effect of amphotericin B and trimethoprim lactate on selectivity.  |  Faur, YC., et al. 1973. Health Lab Sci. 10: 55-60. PMID: 4633803
  11. Trimethoprim for the prevention of overgrowth by swarming Proteus in the cultivation of gonococci.  |  Odegaard, K. 1971. Acta Pathol Microbiol Scand B Microbiol Immunol. 79: 545-8. PMID: 5000798
  12. Neisseria gonorrhoeae strains inhibited by vancomycin in selective media and correlation with auxotype.  |  Mirrett, S., et al. 1981. J Clin Microbiol. 14: 94-9. PMID: 6790572
  13. The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats.  |  Stone, KJ. 1976. Biochem J. 157: 105-9. PMID: 962851

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trimethoprim lactate salt, 250 mg

sc-237332
250 mg
$373.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Trimethoprim lactate salt, sc-237332, is in white to light yellow crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-04-17
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Rated 5 out of 5 by from OtuechereOtuechere, CA. et al. (PubMed 24285126) reported that virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, Trimethoprim lactate salt. -SCBT Publication Review
Date published: 2015-06-25
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Trimethoprim lactate salt is rated 5.0 out of 5 by 1.
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