Molecular structure of Trimethoprim, CAS Number: 738-70-5
Trimethoprim (CAS 738-70-5)
See product citations (4)
Alternate Names:
Trimpex
Application:
Trimethoprim is an antibacterial agent which selectively inhibits dihydrofolate reductase
CAS Number:
738-70-5
Purity:
≥99%
Molecular Weight:
290.32
Molecular Formula:
C14H18N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trimethoprim is an antibacterial agent which selectively inhibits DHFR(dihydrofolate reductase) in prokaryotic microorganisms. in addition, trimethoprim is often combined with sulfamethoxazole (sc-208405) to inhibit the growth of Staphylococcus aureus. Studies suggest that electro-oxidation of trimethoprim is pH dependent and irreversible. Alternate studies show that trimethoprim can synergize with oxygen causing an increase in oxygen tensions in vitro, which decreases the minimal inhibitory concentrations of trimethoprim resulting in bactericidal effects.
Trimethoprim (CAS 738-70-5) References
- Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode. | Rajith, L. and Kumar, KG. 2010. Drug Test Anal. 2: 436-41. PMID: 20845390
- Antimicrobial activities of trimethoprim/sulfamethoxazole, 5-iodo-2'-deoxyuridine and rifampicin against Staphylococcus aureus. | Zander, J., et al. 2010. Int J Antimicrob Agents. 36: 562-5. PMID: 20947313
- Photolytic degradation of sulfamethoxazole and trimethoprim using UV-A, UV-C and vacuum-UV (VUV). | Kim, HY., et al. 2015. J Environ Sci Health A Tox Hazard Subst Environ Eng. 50: 292-300. PMID: 25594122
- Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white. | Bilandžić, N., et al. 2015. Food Chem. 178: 32-7. PMID: 25704680
- Pharmacokinetics of trimethoprim in the rat. | Tu, YH., et al. 1989. J Pharm Sci. 78: 556-60. PMID: 2778654
- Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry. | Psutka, JM., et al. 2018. Anal Chem. 90: 5352-5357. PMID: 29570980
- A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. | Wang, X., et al. 2018. Bioconjug Chem. 29: 1729-1735. PMID: 29660287
- Trimethoprim susceptibility in E. coli community-acquired urinary tract infections in France. | Duployez, C., et al. 2018. Med Mal Infect. 48: 410-413. PMID: 29673879
- Halogenated trimethoprim derivatives as multidrug-resistant Staphylococcus aureus therapeutics. | Nilchan, N., et al. 2018. Bioorg Med Chem. 26: 5343-5348. PMID: 29784273
- Sonochemical degradation of trimethoprim in water matrices: Effect of operating conditions, identification of transformation products and toxicity assessment. | Arvaniti, OS., et al. 2020. Ultrason Sonochem. 67: 105139. PMID: 32348950
- Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. | Lee, IK., et al. 2022. J Clin Invest. 132: PMID: 36106638
- Trimethoprim: mechanisms of action, antimicrobial activity, bacterial resistance, pharmacokinetics, adverse reactions, and therapeutic indications. | Gleckman, R., et al. 1981. Pharmacotherapy. 1: 14-20. PMID: 6985448
- Introduction of trimethoprim: a mixed blessing. | Gleckman, RA. 1981. Urology. 17: 460-1. PMID: 7233660
- Treatment of experimental staphylococcal osteomyelitis with rifampin and trimethoprim, alone and in combination. | Norden, CW. and Keleti, E. 1980. Antimicrob Agents Chemother. 17: 591-4. PMID: 7396451
- Interaction of increased pressures of oxygen and sulfonamides on the in vitro and in vivo growth of pathogenic bacteria. | Keck, PE., et al. 1980. Undersea Biomed Res. 7: 95-106. PMID: 7404854
Inhibitor of:
AICAR transformylase, ALDH1L2, Basal bodies, BC014805, Brucella abortus, Brucella abortus LPS, C20orf54, CNF2, CRS1C-2, CRS4C-5, cryptdin 3, cSHMT, Cyp2c29, Cyp2c65, Cyp2c66, Cyp2c69, CYP2C8, CYPOR, DHFR, DHFRL1, E. coli, EG628518, Enrofloxacin, Enterobacter cloacae, Enzyme, exonucleasefamily surface anchored protein, Folate, Folic Acid, FRP-1, GRAMD2, H. influenzae B, HCP1 (SLC46A1), Inhibitors, Isoc2b, Lex A, MATE1, MFT, MRSA, mSHMT, MSR, MTHFD2L, MTHFR, MTHFS, MTHFSD, MTR, Oct-2, PCBD2, Pneumocystis carinii, Salmonella (Enterobacterales), Salmonella paratyphi 0-2, Salmonella typhimurium 0-4, Shigella dysenteriae, SLC22A15, TaR, THTPA, TPMT, and UAP1.Activator of:
Ciprofloxacin, DHFR, DTYMK, GGH, MTHFS, Pneumocystis carinii, RFC-1, Slc22a22, SPR-5, and TDG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trimethoprim, 5 g | sc-203302 | 5 g | $67.00 | |||
Trimethoprim, 25 g | sc-203302A | 25 g | $161.00 | |||
Trimethoprim, 250 g | sc-203302B | 250 g | $255.00 | |||
Trimethoprim, 1 kg | sc-203302C | 1 kg | $721.00 | |||
Trimethoprim, 5 kg | sc-203302D | 5 kg | $3401.00 |