Molecular structure of Trimebutine base, CAS Number: 39133-31-8
Trimebutine base (CAS 39133-31-8)
Alternate Names:
3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
Application:
Trimebutine base is An opioid receptor agonist
CAS Number:
39133-31-8
Molecular Weight:
387.47
Molecular Formula:
C22H29NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Trimebutine base is an opioid receptor agonist. Trimebutine base is an activator of KOR, DOR and MOR.
Trimebutine base (CAS 39133-31-8) References
- High-performance liquid chromatographic determination of trimebutine and its major metabolite, N-monodesmethyl trimebutine, in rat and human plasma. | Joo, EH., et al. 1999. J Chromatogr B Biomed Sci Appl. 723: 239-46. PMID: 10080651
- Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. | Chevalier, E., et al. 2004. Life Sci. 76: 319-29. PMID: 15531383
- Determination of trimebutine in pharmaceuticals by differential pulse voltammetry at a glassy carbon electrode. | Adhoum, N. and Monser, L. 2005. J Pharm Biomed Anal. 38: 619-23. PMID: 15967289
- Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors. | Taniyama, K., et al. 1991. Gastroenterology. 101: 1579-87. PMID: 1659547
- Effects of trimebutine on cytosolic Ca2+ and force transitions in intestinal smooth muscle. | Nagasaki, M., et al. 1991. Eur J Pharmacol. 195: 317-21. PMID: 1868878
- General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride. | Megens, AA., et al. 1991. Arzneimittelforschung. 41: 631-4. PMID: 1930352
- Trimebutine as a modulator of gastrointestinal motility. | Lee, HT. and Kim, BJ. 2011. Arch Pharm Res. 34: 861-4. PMID: 21725804
- Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. | Xu, J., et al. 2017. Dis Model Mech. 10: 1117-1128. PMID: 28714852
- Interactions of trimebutine with guinea-pig opioid receptors. | Roman, F., et al. 1987. J Pharm Pharmacol. 39: 404-7. PMID: 2886594
- Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent. | Fan, YP., et al. 2018. Front Pharmacol. 9: 664. PMID: 29977208
- The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs. | Hussain, Z., et al. 2018. J Neurogastroenterol Motil. 24: 669-675. PMID: 30114898
- Green conventional and first-order derivative fluorimetry methods for determination of trimebutine and its degradation product (eudesmic acid). Emphasis on the solvent and pH effects on their emission spectral properties. | El-Shaheny, R. and Belal, F. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 226: 117603. PMID: 31614275
- Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages. | Ogawa, N., et al. 2021. Arch Biochem Biophys. 711: 109029. PMID: 34517011
- The involvement of opiate receptors in the effects of trimebutine on intestinal motility in the conscious dog. | Fioramonti, J., et al. 1984. J Pharm Pharmacol. 36: 618-21. PMID: 6149288
- Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells. | Nagasaki, M., et al. 1993. Br J Pharmacol. 110: 399-403. PMID: 8220900
Activator of:
DOR, KOR, and MOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trimebutine base, 25 g | sc-204927 | 25 g | $91.00 | |||
Trimebutine base, 50 g | sc-204927A | 50 g | $400.00 |