TRIM68 Antibody (5G2): sc-517118
- TRIM68 Antibody (5G2) is a mouse monoclonal IgG2a κ TRIM68 antibody provided at 100 µg/ml
- raised against amino acids 181-280 representing partial length TRIM68 of human origin
- recommended for detection of TRIM68 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRIM68 Antibody (5G2). This work is in progress.
TRIM68 Antibody (5G2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TRIM68 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-TRIM68 antibody (5G2) is available as the non-conjugated format. TRIM68, also known as tripartite motif-containing protein 68 or RNF137, is a 485 amino acid protein that plays a crucial role in cellular processes by localizing to the perinuclear region of the cytoplasm. This localization positions TRIM68 to interact with various nuclear proteins, including the androgen receptor (AR), thereby enhancing AR′s transcriptional activity, which is vital for regulating gene expression in response to androgens. TRIM68 is expressed in multiple tissues, with notably higher levels in the prostate, spleen, and fetal liver, and TRIM68′s involvement in the modulation of AR activity links TRIM68 to prostate cancer, where TRIM68 is often overexpressed. Furthermore, TRIM68 has been implicated in autoimmune responses, particularly in conditions such as systemic lupus erythematosus, primary Sjögren syndrome, and HIV-1 infection, making TRIM68 a potential therapeutic target for both cancer and autoimmune diseases.
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TRIM68 Antibody (5G2) References:
- DNA cloning using in vitro site-specific recombination. | Hartley, JL., et al. 2000. Genome Res. 10: 1788-95. PMID: 11076863
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. | Simpson, JC., et al. 2000. EMBO Rep. 1: 287-92. PMID: 11256614
- SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus. | Billaut-Mulot, O., et al. 2001. J Clin Invest. 108: 861-9. PMID: 11560955
- A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. | Chang, GT., et al. 2001. Eur J Cancer. 37: 2129-34. PMID: 11597395
- Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells. | Horii, K., et al. 2007. Mol Cancer Res. 5: 383-91. PMID: 17426252
- TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. | Miyajima, N., et al. 2008. Cancer Res. 68: 3486-94. PMID: 18451177
- TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems. | Wynne, C., et al. 2014. PLoS One. 9: e101503. PMID: 24999993
- TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Gene Biomarkers for Osteosarcoma Prognosis. | Jiang, J., et al. 2021. Front Oncol. 11: 643104. PMID: 33968741
- RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68. | Nie, Q., et al. 2023. Eur J Med Res. 28: 552. PMID: 38042806
- PPA1, TRIM68 and FBXO46: Potential Therapeutic Targets for Triple Negative Breast Cancer. | Haider, F., et al. 2025. Curr Protein Pept Sci.. PMID: 39754775
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIM68 Antibody (5G2) | sc-517118 | 100 µg/ml | $322.00 |