TRIM Antibody (TRIM-04): sc-51711
- TRIM Antibody (TRIM-04) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against amino acids 29-186 of TRIM of human origin
- recommended for detection of TRIM of human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRIM Antibody (TRIM-04). This work is in progress.
TRIM Antibody (TRIM-04) is a mouse monoclonal IgG2a antibody that detects TRIM in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). TRIM is a crucial type III transmembrane protein that plays a significant role in T-cell receptor signaling by interacting with the TCR-CD3ζ complex in human T lymphocytes and T cell lines. TRIM (TRIM-04) antibody recognizes a unique structure, which includes an 8-amino acid extracellular domain and an intracellular domain featuring four potential phosphorylation sites and eight tyrosine residues, three of which are known to facilitate SH2-mediated interactions with other signaling proteins. The proper functioning of TRIM is vital for T-cell activation and immune response, as TRIM modulates the signaling pathways that are essential for T-cell proliferation and differentiation. The human TRIM gene is located on chromosome 3q13, a region associated with susceptibility to rheumatoid arthritis, and is situated near the genes encoding important T-cell costimulatory molecules such as CD28, CD86, and CD80. TRIM is predominantly expressed in T-cells and natural killer cells, with localization at the cell membrane allowing TRIM to effectively associate with CD3ζ and CD3ε, thereby influencing T-cell signaling dynamics. Anti-TRIM antibody (TRIM-04) serves as an invaluable tool for researchers studying T-cell biology and related immunological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIM Antibody (TRIM-04) | sc-51711 | 100 µg/ml | $316.00 |