Triisopropylsilanethiol (CAS 156275-96-6)
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Triisopropylsilanethiol is a silylating agent used primarily in organic chemistry to introduce triisopropylsilyl (TIPS) protective groups, particularly for the protection of hydroxyl and thiol groups in sensitive molecules during multi-step synthetic procedures. Its utility is appreciated in the synthesis of complex organic molecules, where it can increase the steric bulk and improve the selectivity of reactions by blocking potential reaction sites. Chemists employ this reagent for its ability to render protected intermediates more stable towards various reaction conditions, which is for the successful completion of lengthy syntheses. In materials science, triisopropylsilanethiol is investigated for its potential in creating self-assembled monolayers on gold surfaces due to its thiol functional group, which can form strong bonds with metals, thus modifying surface properties for applications in nanotechnology and sensor design.
Triisopropylsilanethiol (CAS 156275-96-6) References
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- One-pot synthesis of unsymmetrical diaryl thioethers by palladium-catalyzed coupling of two aryl bromides and a thiol surrogate. | Fernández-Rodríguez, MA. and Hartwig, JF. 2010. Chemistry. 16: 2355-9. PMID: 20112309
- Simple procedure for mono- and bis-end-functionalization of regioregular poly(3-hexylthiophene)s using chalcogens. | Okamoto, K. and Luscombe, CK. 2014. Chem Commun (Camb). 50: 5310-2. PMID: 24192778
- Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds. | Loh, YY., et al. 2017. Science. 358: 1182-1187. PMID: 29123019
- Visible light-promoted synthesis of ureas and formamides from amines and CO2. | Zhang, Q., et al. 2022. Chem Commun (Camb). 58: 4599-4602. PMID: 35311867
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triisopropylsilanethiol, 1 g | sc-229583 | 1 g | $67.00 | |||
Triisopropylsilanethiol, 5 g | sc-229583A | 5 g | $223.00 |