Date published: 2026-2-27

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Trihexylphosphine (CAS 4168-73-4)

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CAS Number:
4168-73-4
Molecular Weight:
286.48
Molecular Formula:
C18H39P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trihexylphosphine, a phosphine compound, exhibits versatile applications as an extractant, a synthesis method for antimicrobial agents, and a cross-linking agent for polymers and organic molecules. Notably, when combined with fluorescein, Trihexylphosphine forms a luminous compound under the presence of light and oxygen. Its broad-spectrum antimicrobial activity extends to bacteria, fungi, viruses, and parasites. Furthermore, Trihexylphosphine′s utility extends beyond antimicrobial applications. Its role as a cross-linking agent enables the synthesis of polymers and various organic molecules, facilitating the development of new materials and compounds. By facilitating cross-linking reactions, it contributes to the formation of stable and structurally robust materials. Another noteworthy property of Trihexylphosphine lies in its potential as an industrial preparation for chlorination reactions. When subjected to hydrochloric acid, it has the capacity to produce chlorine gas (Cl2). This characteristic makes Trihexylphosphine a valuable resource for chlorination processes in industrial settings.


Trihexylphosphine (CAS 4168-73-4) References

  1. [Bis(3,5-dimethylpyrazol-1-yl-kappaN2)dithioacetato-kappaS](triphenylphosphine-kappaP)copper(I).  |  Liu, LL., et al. 2007. Acta Crystallogr C. 63: m513-5. PMID: 17989468
  2. Cycloaurated triphenylphosphine-sulfide and -selenide.  |  Kilpin, KJ., et al. 2010. Dalton Trans. 39: 1855-64. PMID: 20449432
  3. Bis(triphenylphosphine)silver(i) perrhenate, a cyclic dimer.  |  Deiser, F., et al. 2015. Chem Commun (Camb). 51: 6746-8. PMID: 25787677
  4. Inorganic Triphenylphosphine.  |  Gorman, AD., et al. 2018. Angew Chem Int Ed Engl. 57: 15802-15806. PMID: 30311990
  5. Triphenylphosphine-assisted dehydroxylative Csp3-N bond formation via electrochemical oxidation.  |  Xu, Z., et al. 2019. Chem Commun (Camb). 55: 15089-15092. PMID: 31782432
  6. Direct and Scalable Electroreduction of Triphenylphosphine Oxide to Triphenylphosphine.  |  Manabe, S., et al. 2020. J Am Chem Soc. 142: 3024-3031. PMID: 31948233
  7. Triphenylphosphine-Based Covalent Organic Frameworks and Heterogeneous Rh-P-COFs Catalysts.  |  Liu, Y., et al. 2020. Chemistry. 26: 12134-12139. PMID: 32488940
  8. Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature.  |  Tamboli, Y., et al. 2021. ACS Omega. 6: 13940-13945. PMID: 34095685
  9. A Comparison of Immobilised Triphenylphosphine and 1-Hydroxybenzotriazole as Mediators of Catch-and-Release Acylation Under Flow Conditions.  |  Tadros, J., et al. 2022. Chem Asian J. 17: e202101308. PMID: 35048529
  10. Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(I) coordinated cluster for enhanced chemodynamic therapy.  |  You, X., et al. 2022. Dalton Trans. 51: 5782-5787. PMID: 35353878
  11. A triphenylphosphine coordinated cinnamaldehyde-derived copper(I) Fenton-like agent with mitochondrial aggregation damage for chemodynamic therapy.  |  Hong, Z., et al. 2022. J Mater Chem B. 10: 5086-5094. PMID: 35730927
  12. Triphenylphosphine gold(I) derivatives promote antiviral effects against the Chikungunya virus.  |  Aires, RL., et al. 2022. Metallomics. 14: PMID: 35894863
  13. Application Prospects of Triphenylphosphine-Based Mitochondria-Targeted Cancer Therapy.  |  Cheng, X., et al. 2023. Cancers (Basel). 15: PMID: 36765624

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trihexylphosphine, 25 ml

sc-296621
25 ml
$444.00