Molecular structure of Trigonelline, CAS Number: 535-83-1
Trigonelline (CAS 535-83-1)
Alternate Names:
N-Methylnicotinate
CAS Number:
535-83-1
Molecular Weight:
137.14
Molecular Formula:
C7H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Trigonelline, an alkaloid found in coffee and fenugreek seed, displays a range of biological activities. It exhibits phytoestrogenic and anti-adipogenic properties. It has the ability to reduce early glucose and insulin responses, potentially aiding in the regulation of blood sugar levels. Trigonelline exerts its effects through inhibiting the Nrf2 transcription factor and PPAR-γ.
Trigonelline (CAS 535-83-1) References
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis. | Roh, JL., et al. 2017. Redox Biol. 11: 254-262. PMID: 28012440
- Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. | Shin, D., et al. 2018. Free Radic Biol Med. 129: 454-462. PMID: 30339884
- The sources and mechanisms of bioactive ingredients in coffee. | Hu, GL., et al. 2019. Food Funct. 10: 3113-3126. PMID: 31166336
- Trigonelline: An alkaloid with anti-degranulation properties. | Nugrahini, AD., et al. 2020. Mol Immunol. 118: 201-209. PMID: 31896496
- Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway. | Qiu, Z., et al. 2020. Chem Biol Interact. 317: 108946. PMID: 31935362
- Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice. | Casili, G., et al. 2020. J Neuroinflammation. 17: 59. PMID: 32066464
- Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats. | Rathi, A., et al. 2020. Drug Res (Stuttg). 70: 257-264. PMID: 32289834
- Trigonelline induces browning in 3T3-L1 white adipocytes. | Choi, M., et al. 2021. Phytother Res. 35: 1113-1124. PMID: 33015893
- Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells. | Fouzder, C., et al. 2021. Toxicol In Vitro. 70: 105038. PMID: 33148531
- Trigonelline, An Alkaloid From Leonurus japonicus Houtt., Suppresses Mast Cell Activation and OVA-Induced Allergic Asthma. | Zhang, W., et al. 2021. Front Pharmacol. 12: 687970. PMID: 34421593
- Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway. | Chen, C., et al. 2022. Diabetol Metab Syndr. 14: 28. PMID: 35139912
- Trigonelline prevents kidney stone formation processes by inhibiting calcium oxalate crystallization, growth and crystal-cell adhesion, and downregulating crystal receptors. | Peerapen, P., et al. 2022. Biomed Pharmacother. 149: 112876. PMID: 35367760
- The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms. | Liang, Y., et al. 2023. Biochimie. 206: 93-104. PMID: 36257493
Inhibitor of:
AFX1, and SKN-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trigonelline, 25 mg | sc-484427 | 25 mg | $403.00 |