Date published: 2025-9-18

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Triglyme (CAS 112-49-2)

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Alternate Names:
2,5,8,11-Tetraoxadodecane; 1,2-Bis(2-methoxyethoxy)ethane; Ansul Ether 161
CAS Number:
112-49-2
Molecular Weight:
178.23
Molecular Formula:
C8H18O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triglyme is a glycol ether, specifically triethylene glycol dimethyl ether, characterized by its structure consisting of three ethylene glycol units linked by ether bonds with two terminal methyl groups. As a high boiling point solvent, Triglyme is prized in research for its exceptional solvating abilities, particularly for both polar and non-polar compounds, facilitating its use in diverse chemical reactions and processes. Its chemical stability and low volatility make it ideal for use in high-temperature reactions without significant evaporation or degradation. Triglyme′s unique properties stem from its ether linkages and terminal methyl groups, which contribute to its low viscosity and excellent solvent characteristics. These properties are particularly advantageous in the synthesis of large, complex organic molecules where maintaining the integrity of delicate structures is crucial. In the field of electrochemistry, Triglyme has been explored as a component of electrolyte solutions in lithium batteries. Its ability to dissolve lithium salts while providing a stable medium for ionic transport enhances the performance and longevity of these batteries. Additionally, its inert nature and resistance to forming complexes with lithium ions make it a valuable research tool in studying the fundamental properties of electrolyte solutions and their interactions with battery materials.


Triglyme (CAS 112-49-2) References

  1. Plasma-deposited membranes for controlled release of antibiotic to prevent bacterial adhesion and biofilm formation.  |  Hendricks, SK., et al. 2000. J Biomed Mater Res. 50: 160-70. PMID: 10679680
  2. Improved procedures for the generation of diborane from sodium borohydride and boron trifluoride.  |  Kanth, JV. and Brown, HC. 2000. Inorg Chem. 39: 1795-802. PMID: 12526571
  3. Glyme-lithium salt phase behavior.  |  Henderson, WA. 2006. J Phys Chem B. 110: 13177-83. PMID: 16805630
  4. Source identification of high glyme concentrations in the Oder River.  |  Stepien, DK. and Püttmann, W. 2014. Water Res. 54: 307-17. PMID: 24583522
  5. PFC and Triglyme for Li-Air Batteries: A Molecular Dynamics Study.  |  Kuritz, N., et al. 2016. J Phys Chem B. 120: 3370-7. PMID: 26982570
  6. The Solvation Structure of Lithium Ions in an Ether Based Electrolyte Solution from First-Principles Molecular Dynamics.  |  Callsen, M., et al. 2017. J Phys Chem B. 121: 180-188. PMID: 27997213
  7. Interfacial Layering and Screening Behavior of Glyme-Based Lithium Electrolytes.  |  Nojabaee, M., et al. 2018. J Phys Chem Lett. 9: 577-582. PMID: 29323500
  8. Magnesium bis(trifluoromethanesulfonyl)amide complexes with triglyme and asymmetric homologues: phase behavior, coordination structures and melting point reduction.  |  Hashimoto, K., et al. 2018. Phys Chem Chem Phys. 20: 7998-8007. PMID: 29512676
  9. Determining Factor on the Polarization Behavior of Magnesium Deposition for Magnesium Battery Anode.  |  Tuerxun, F., et al. 2020. ACS Appl Mater Interfaces. 12: 25775-25785. PMID: 32395982
  10. Size-selective Catalytic Polymer Acylation with a Molecular Tetrahedron.  |  Sharafi, M., et al. 2020. Chem. 6: 1469-1494. PMID: 32728651
  11. Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system.  |  Fujihira, Y., et al. 2021. Beilstein J Org Chem. 17: 431-438. PMID: 33633811

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triglyme, 1 g

sc-213114
1 g
$300.00