Molecular structure of Trifluoroacetic anhydride, CAS Number: 407-25-0
Trifluoroacetic anhydride (CAS 407-25-0)
Alternate Names:
TFAA
Application:
Trifluoroacetic anhydride is for the preparation of N- and O-trifluoroacetyl derivatives
CAS Number:
407-25-0
Molecular Weight:
210.03
Molecular Formula:
C4F6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trifluoroacetic anhydride is used for the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for GC analysis. Also used in the oxidation of aldehydes to acids, amides or esters. Strong non-oxidizing acid, laboratory reagent, solvent, catalyst. It is used in the laboratory as a model system to study antimicrobial agents and the reaction mechanism of these compounds
Trifluoroacetic anhydride (CAS 407-25-0) References
- Trifluoroacetic anhydride-catalyzed nitration of toluene as an approach to the specific analysis of nitrate by gas chromatography-mass spectrometry. | Smythe, GA., et al. 1999. Nitric Oxide. 3: 67-74. PMID: 10355897
- Trifluoroacetic anhydride-mediated solid-phase version of the Robinson-Gabriel synthesis of oxazoles. | Pulici, M., et al. 2005. J Comb Chem. 7: 463-73. PMID: 15877475
- Trifluoroacetic anhydride-catalyzed oxidation of isonitriles by DMSO: a rapid, convenient synthesis of isocyanates. | Le, HV. and Ganem, B. 2011. Org Lett. 13: 2584-5. PMID: 21491899
- Trifluoroacetic anhydride promoted tandem conjugate addition of boronic acids/acetal ring opening. | Roscales, S. and Csáky, AG. 2012. Org Lett. 14: 1187-9. PMID: 22339156
- One-pot synthesis of thermoplastic mixed paramylon esters using trifluoroacetic anhydride. | Shibakami, M., et al. 2015. Carbohydr Polym. 119: 1-7. PMID: 25563938
- Acylation of cellulose nanocrystals with acids/trifluoroacetic anhydride and properties of films from esters of CNCs. | Huang, F., et al. 2017. Carbohydr Polym. 155: 525-534. PMID: 27702544
- Trifluoroacetic Anhydride Promoted Copper(I)-Catalyzed Interrupted Click Reaction: From 1,2,3-Triazoles to 3-Trifluoromethyl-Substituted 1,2,4-Triazinones. | Wu, W., et al. 2017. Angew Chem Int Ed Engl. 56: 10476-10480. PMID: 28665026
- Elemental tellurium mediated synthesis of 2-(trifluoromethyl)oxazoles using trifluoroacetic anhydride as reagent. | Luo, B. and Weng, Z. 2018. Chem Commun (Camb). 54: 10750-10753. PMID: 30191210
- Transparent and Robust All-Cellulose Nanocomposite Packaging Materials Prepared in a Mixture of Trifluoroacetic Acid and Trifluoroacetic Anhydride. | Guzman-Puyol, S., et al. 2019. Nanomaterials (Basel). 9: PMID: 30841528
- Trifluoroacetic Acid and Trifluoroacetic Anhydride Radical Cations Dissociate near the Ionization Limit. | Lesniak, L., et al. 2019. J Phys Chem A. 123: 6313-6318. PMID: 31251045
- Mono-N-oxidation of heterocycle-fused pyrimidines. | Tang, Y., et al. 2021. Dalton Trans. 50: 2143-2148. PMID: 33491730
- Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C-O Bond Fragmentation of Trifluoroacetic Anhydride. | Zhang, K., et al. 2021. Angew Chem Int Ed Engl. 60: 22487-22495. PMID: 34289531
- Trifluoromethylations of (Hetero)arenes and Polarized Alkenes Using Trifluoroacetic Anhydride under Photoredox Catalysis. | Song, Y., et al. 2023. Org Lett. 25: 2372-2376. PMID: 36971301
Substrate of:
Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trifluoroacetic anhydride, 25 g | sc-213113 | 25 g | $32.00 | |||
Trifluoroacetic anhydride, 100 g | sc-213113A | 100 g | $87.00 |