Molecular structure of Trifluoroacetic acid, CAS Number: 76-05-1
Trifluoroacetic acid (CAS 76-05-1)
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Alternate Names:
TFA
Application:
Trifluoroacetic acid is a strong non-oxidizing acid
CAS Number:
76-05-1
Purity:
≥99%
Molecular Weight:
114.02
Molecular Formula:
C2HF3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trifluoroacetic acid is a versatile synthetic reagent and effective ion paring reagent for multiple applications. It has a pKa of 0.25 and holds significance in scientific research areas such as organic synthesis, protein structure analysis, and drug synthesis. Its versatility extends to the synthesis of various compounds, including peptides and polymers.
Trifluoroacetic acid (CAS 76-05-1) References
- Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. | Minko, T., et al. 2002. Cancer Chemother Pharmacol. 50: 143-50. PMID: 12172980
- Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. | Scott, SA., et al. 2009. Nat Chem Biol. 5: 108-17. PMID: 19136975
- A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore. | Pauff, SM. and Miller, SC. 2013. J Org Chem. 78: 711-6. PMID: 23167708
- Airborne trifluoroacetic acid and its fraction from the degradation of HFC-134a in Beijing, China. | Wu, J., et al. 2014. Environ Sci Technol. 48: 3675-81. PMID: 24628386
- Trifluoroacetic acid-promoted Michael addition-cyclization reactions of vinylogous carbamates. | Naganaboina, RT., et al. 2014. Org Biomol Chem. 12: 3366-70. PMID: 24756460
- Sources, fates, toxicity, and risks of trifluoroacetic acid and its salts: Relevance to substances regulated under the Montreal and Kyoto Protocols. | Solomon, KR., et al. 2016. J Toxicol Environ Health B Crit Rev. 19: 289-304. PMID: 27351319
- Trifluoroacetic acid: Three times the fluoride, three times the toxicity? | Sun, C. and Corbett, B. 2018. Am J Emerg Med. 36: 529.e1-529.e2. PMID: 29248268
- Application of Trifluoroacetic Acid as a Theranostic Agent for Chemical Ablation of Solid Tissue. | Einstein, SA., et al. 2020. J Vasc Interv Radiol. 31: 169-175. PMID: 31537410
- Distribution characteristics of trifluoroacetic acid in the environments surrounding fluorochemical production plants in Jinan, China. | Xie, G., et al. 2020. Environ Sci Pollut Res Int. 27: 983-991. PMID: 31820231
- Fluorochemicals biodegradation as a potential source of trifluoroacetic acid (TFA) to the environment. | Sun, M., et al. 2020. Chemosphere. 254: 126894. PMID: 32957292
- Evaluation of strategies for overcoming trifluoroacetic acid ionization suppression resulted in single-column intact level, middle-up, and bottom-up reversed-phase LC-MS analyses of antibody biopharmaceuticals. | Khalikova, MA., et al. 2021. Talanta. 233: 122512. PMID: 34215127
- Insufficient evidence for the existence of natural trifluoroacetic acid. | Joudan, S., et al. 2021. Environ Sci Process Impacts. 23: 1641-1649. PMID: 34693963
- Efficient removal of trifluoroacetic acid from water using surface-modified activated carbon and electro-assisted desorption. | Zhou, J., et al. 2022. J Hazard Mater. 436: 129051. PMID: 35580494
- Switchable Reductive N-Trifluoroethylation and N-Trifluoroacetylation of Indoles with Trifluoroacetic Acid and Trimethylamine Borane. | Zeng, YF., et al. 2022. Org Lett. 24: 7440-7445. PMID: 36173131
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trifluoroacetic acid, 1 ml | sc-216010 | 1 ml | $56.00 | |||
Trifluoroacetic acid, 100 ml | sc-216010A | 100 ml | $148.00 | |||
Trifluoroacetic acid, 500 ml | sc-216010C | 500 ml | $561.00 |