Date published: 2025-12-31

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Trifluoroacetaldehyde, solution (CAS 421-53-4)

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Alternate Names:
2,2,2-Trifluoroethane-1,1-diol
Application:
Trifluoroacetaldehyde, solution is a reagent used in the synthesis of GABAB activators
CAS Number:
421-53-4
Molecular Weight:
116.04
Molecular Formula:
C2H3F3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trifluoroacetaldehyde, solution, also known as 2,2,2-trifluoroethanal, is a fluorinated aldehyde. It stands out in the field of organic chemistry due to its unique electronic properties conferred by the three fluorine atoms attached to the carbon atom. These fluorine atoms significantly withdraw electron density through their inductive effect, which stabilizes the carbonyl group and enhances its reactivity towards nucleophilic addition reactions. This characteristic makes trifluoroacetaldehyde, solution a valuable reagent in the synthesis of fluorinated organic compounds, offering a pathway to introduce fluorine into molecules, which is of particular interest in the development of materials and compounds with altered physical and chemical properties. Its utility in research extends to the study of reaction mechanisms involving carbonyl compounds, serving as a model compound to understand the effects of electronegativity and steric hindrance on reactivity and stability. Due to its highly reactive nature, trifluoroacetaldehyde, solution is also employed in various synthetic strategies, including the formation of fluorinated alcohols, acids, and their derivatives, which are for exploring new materials and understanding the role of fluorine in organic molecules.


Trifluoroacetaldehyde, solution (CAS 421-53-4) References

  1. Trifluoromethylallylation of Heterocyclic C-H Bonds with Allylic Carbonates under Rhodium Catalysis.  |  Choi, M., et al. 2016. J Org Chem. 81: 4771-8. PMID: 27187625
  2. Redox-Neutral Rh(III)-Catalyzed Olefination of Carboxamides with Trifluoromethyl Allylic Carbonate.  |  Park, J., et al. 2016. J Org Chem. 81: 11353-11359. PMID: 27794608

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trifluoroacetaldehyde, solution, 10 g

sc-280152
10 g
$173.00