Date published: 2025-9-26

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Triethyl orthoformate (CAS 122-51-0)

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Alternate Names:
1,1,1-Triethoxymethane; Orthoformic acid triethyl ester
Application:
Triethyl orthoformate is a reagent useful for acetylization and imidic ester formation
CAS Number:
122-51-0
Purity:
≥97%
Molecular Weight:
148.20
Molecular Formula:
C7H16O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triethyl orthoformate, an organic compound, manifests as a colorless, volatile liquid with a pleasant scent and serves as a widely employed organic solvent. Its role as a reagent in the laboratory facilitates the synthesis of diverse organic compounds. Moreover, it proves valuable in polymer synthesis and serves as a stabilizer in polymer production processes. As an organic solvent, Triethyl orthoformate demonstrates its ability to dissolve and disperse a wide range of organic compounds within various mixtures. With its polar nature, it exhibits high solubility for both organic and inorganic compounds. Additionally, it displays excellent solvent properties for polymers, effectively dissolving and dispersing them within mixtures.


Triethyl orthoformate (CAS 122-51-0) References

  1. Convenient synthesis of 4,6-di-O-benzyl-myo-inositol and myo-inositol 1,3,5-orthoesters.  |  Praveen, T. and Shashidhar, MS. 2001. Carbohydr Res. 330: 409-11. PMID: 11270820
  2. The reactions of pindolol, mepindolol, carazolol, and related model compounds with triethyl orthoformate: pathways and products of a new colour reaction.  |  Pindur, U. and Witzel, H. 1990. Arch Pharm (Weinheim). 323: 427-32. PMID: 1978656
  3. A rapid route to aminocyclopropanes via carbamatoorganozinc carbenoids.  |  Ishikawa, S., et al. 2013. Angew Chem Int Ed Engl. 52: 10060-3. PMID: 23913871
  4. Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis.  |  Yar, M., et al. 2015. Mater Sci Eng C Mater Biol Appl. 56: 154-64. PMID: 26249576
  5. Triethyl orthoformate covalently cross-linked chitosan-(poly vinyl) alcohol based biodegradable scaffolds with heparin-binding ability for promoting neovascularisation.  |  Shahzadi, L., et al. 2016. J Biomater Appl. 31: 582-593. PMID: 27189757
  6. Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities of the Products.  |  Miszczyk, P., et al. 2017. Molecules. 22: PMID: 28208725
  7. Synthesis and Characterization of Ethyl Formate Precursor for Activated Release Application.  |  Zaitoon, A., et al. 2019. J Agric Food Chem. 67: 13914-13921. PMID: 31757122
  8. Three-Component Reaction of Diamines with Triethyl Orthoformate and Diethyl Phosphite and Anti-Proliferative and Antiosteoporotic Activities of the Products.  |  Petruczynik, P., et al. 2020. Molecules. 25: PMID: 32245019
  9. Synthesis of Some New Folic Acid-Based Heterocycles of Anticipated Biological Activity.  |  Abu Ali, OA., et al. 2021. Molecules. 26: PMID: 33445770
  10. In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors.  |  Fayed, EA., et al. 2022. Mol Divers. 26: 341-363. PMID: 33895960
  11. Metal-free and solvent-free synthesis of m-terphenyls through tandem cyclocondensation of aryl methyl ketones with triethyl orthoformate.  |  Xiao, X., et al. 2020. RSC Adv. 10: 12113-12118. PMID: 35496630
  12. Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate.  |  Salami, SA., et al. 2022. Molecules. 27: PMID: 35807459
  13. New ecofriendly heterogeneous nano-catalyst for the synthesis of 1-substituted and 5-substituted 1H-tetrazole derivatives.  |  Mashhoori, MS. and Sandaroos, R. 2022. Sci Rep. 12: 15364. PMID: 36100632
  14. Antiproliferative and Antiprostate Cancer Activities of Heterocyclic Compounds Derived from Cyclohexane-1,4-dione.  |  Mohareb, RM. and Abdo, NYM. 2022. Acta Chim Slov. 69: 700-713. PMID: 36196826
  15. Imidazolylpyrrolone-Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma.  |  Sousa, A., et al. 2023. ChemMedChem. 18: e202200519. PMID: 36310147

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triethyl orthoformate, 500 ml

sc-397864
500 ml
$56.00

Triethyl orthoformate, 1 L

sc-397864A
1 L
$85.00