Triclosan O-β-D-Glucuronide Sodium Salt (CAS 63156-12-7 free acid)
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Triclosan O-β-D-Glucuronide sodium salt is a metabolite of triclosan, resulting from the conjugation of triclosan with glucuronic acid. This modification enhances the molecule′s solubility in water, facilitating its excretion. The addition of the sodium salt further increases its solubility, making it more amenable for studies in aqueous solutions. The formation of glucuronide conjugates is a common biochemical pathway for the detoxification and elimination of both endogenous substances and xenobiotics. The conjugation with glucuronic acid makes compounds more polar and hence more easily excreted in the urine or bile. In environmental and analytical chemistry, the detection of Triclosan O-β-D-Glucuronide sodium salt in water sources or biological samples can be an indicator of triclosan exposure or pollution.
Triclosan O-β-D-Glucuronide Sodium Salt (CAS 63156-12-7 free acid) References
- Aldehyde oxidase activity in fresh human skin. | Manevski, N., et al. 2014. Drug Metab Dispos. 42: 2049-57. PMID: 25249692
- Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation. | Manevski, N., et al. 2015. Drug Metab Dispos. 43: 126-39. PMID: 25339109
- Determination of 24 personal care products in fish bile using hybrid solvent precipitation and dispersive solid phase extraction cleanup with ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. | Yao, L., et al. 2018. J Chromatogr A. 1551: 29-40. PMID: 29650477
- Bioaccumulation and Biotransformation of Triclosan and Galaxolide in the Freshwater Oligochaete Limnodrilus hoffmeisteri in a Water/Sediment Microcosm. | Peng, FJ., et al. 2018. Environ Sci Technol. 52: 8390-8398. PMID: 30010330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triclosan O-β-D-Glucuronide Sodium Salt, 1 mg | sc-474873 | 1 mg | $340.00 | |||
Triclosan O-β-D-Glucuronide Sodium Salt, 10 mg | sc-474873A | 10 mg | $2400.00 | |||
Triclosan O-β-D-Glucuronide Sodium Salt, 50 mg | sc-474873B | 50 mg | $7500.00 | |||
Triclosan O-β-D-Glucuronide Sodium Salt, 100 mg | sc-474873C | 100 mg | $11500.00 |