Date published: 2026-2-18

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Trichloroacetamide (CAS 594-65-0)

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CAS Number:
594-65-0
Molecular Weight:
162.40
Molecular Formula:
C2H2Cl3NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trichloroacetamide acts as a nucleophilic acylating agent, reacting with various nucleophiles to form amide derivatives. Its mechanism of action involves the substitution of the chlorine atoms by nucleophiles, leading to the formation of amide bonds. Trichloroacetamide plays a role in the synthesis of amides and related compounds, contributing to the development of new materials and compounds for experimental purposes. Trichloroacetamide′s mechanism of action involves its ability to undergo nucleophilic substitution reactions, allowing for the modification of organic molecules in a controlled manner. Trichloroacetamide′s function lies in its reactivity and its role in the synthesis of amide derivatives.


Trichloroacetamide (CAS 594-65-0) References

  1. One-pot transformation of trichloroacetamide into readily deprotectable carbamates.  |  Nishikawa, T., et al. 2006. Org Lett. 8: 3263-5. PMID: 16836381
  2. Identifying health effects of exposure to trichloroacetamide using transcriptomics and metabonomics in mice (Mus musculus).  |  Zhang, Y., et al. 2013. Environ Sci Technol. 47: 2918-24. PMID: 23406383
  3. Metagenomic and metabolomic analysis of the toxic effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in mice.  |  Zhang, Y., et al. 2015. J Proteome Res. 14: 1752-61. PMID: 25609144
  4. Acetonitrile and N-Chloroacetamide Formation from the Reaction of Acetaldehyde and Monochloramine.  |  Kimura, SY., et al. 2015. Environ Sci Technol. 49: 9954-63. PMID: 26167888
  5. One-Step Transformation of Trichloroacetamide into Isonitrile.  |  Adachi, M., et al. 2017. Org Lett. 19: 380-383. PMID: 28032769
  6. Rearrangement of Benzylic Trichloroacetimidates to Benzylic Trichloroacetamides.  |  Adhikari, AA., et al. 2017. J Org Chem. 82: 3982-3989. PMID: 28323428
  7. [Removal Efficiency of Trichloroacetamide by UV/Sodium Sulfite].  |  Fu, ZX., et al. 2019. Huan Jing Ke Xue. 40: 2271-2277. PMID: 31087866
  8. High-performance reductive decomposition of trichloroacetamide by the vacuum-ultraviolet/sulfite process: Kinetics, mechanism and combined toxicity risk.  |  Huang, H., et al. 2022. Water Res. 225: 119122. PMID: 36152441
  9. In vitro toxicity assessment of haloacetamides via a toxicogenomics assay.  |  Li, D., et al. 2023. Environ Toxicol Pharmacol. 97: 104026. PMID: 36455839
  10. Synthesis of Dimeric Lewis A and Lewis B-Lewis A Tumor-Associated Carbohydrate Antigen Oligosaccharide Fragments.  |  Davidson, J., et al. 2023. J Org Chem. 88: 5554-5562. PMID: 37023470
  11. A Review of Traditional and Emerging Residual Chlorine Quenchers on Disinfection By-Products: Impact and Mechanisms.  |  Li, X., et al. 2023. Toxics. 11: PMID: 37235225
  12. The effect of the addition of trichloroacetamide and chloroform to the rumen of sheep on the fermentation.  |  Clapperton, JL. 1973. Proc Nutr Soc. 32: 57A-58A. PMID: 4791057
  13. [On the fungicidic action of some aromatic trichloroacetamide derivatives].  |  Shomova, EA., et al. 1965. Mikrobiologiia. 34: 715-9. PMID: 5871144

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trichloroacetamide, 5 g

sc-251306
5 g
$27.00