Molecular structure of Triacsin C Solution in DMSO, CAS Number: 76896-80-5
Triacsin C Solution in DMSO (CAS 76896-80-5)
See product citations (14)
Alternate Names:
2,4,7-Undecatrienal nitrosohydrazone;WS1228A
Application:
Triacsin C Solution in DMSO is a hypotensive vasodilator, inhibitor of long-chain fatty acid acyl-CoA synthetase, neutrophils and β-cells
CAS Number:
76896-80-5
Purity:
≥90%
Molecular Weight:
207.27
Molecular Formula:
C11H17N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Triacsin C Solution in DMSO was originally isolated from a Streptomyces aureofaciens culture. The compound is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) in intact cells and the nonspecific ACSL in cell sonicates (IC50=3.6-8.7 muM). Triacsin C Solution in DMSO may act to inhibit de novo synthesis of triacylglycerol, diacylglycerol, cholesterol esters, and phospholipids. The inhibitory effect of Triacsin C prevents degranulation by human neutrophils through superoxide anion generation inhibition, thus inhibiting neutrophil activity. Triacsin C Solution in DMSO has been classified as a hypotensive vasodilator which may act by increasing methacholine-induced NO synthesis. The compound has also been reported to inhibit beta-cells by abolishing L-type Ca2+ CP (L-type Ca2+) channel modulation.
Triacsin C Solution in DMSO (CAS 76896-80-5) References
- Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. | Weis, MT., et al. 2004. Cardiovasc Res. 63: 338-46. PMID: 15249192
- Differential modulation of L-type calcium channel subunits by oleate. | Tian, Y., et al. 2008. Am J Physiol Endocrinol Metab. 294: E1178-86. PMID: 18430963
- Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase. | Hartman, EJ., et al. 1989. Prostaglandins. 37: 655-71. PMID: 2505330
- Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins. | Knoll, LJ., et al. 1995. J Biol Chem. 270: 20090-7. PMID: 7650027
- Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils. | Korchak, HM., et al. 1994. J Biol Chem. 269: 30281-7. PMID: 7982939
- Acylglycerol recycling from triacylglycerol to phospholipid, not lipase activity, is defective in neutral lipid storage disease fibroblasts. | Igal, RA. and Coleman, RA. 1996. J Biol Chem. 271: 16644-51. PMID: 8663220
- Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA. | Igal, RA., et al. 1997. Biochem J. 324 (Pt 2): 529-34. PMID: 9182714
Inhibitor of:
2410131K14Rik, 2900097C17Rik, 5330437I02Rik, AADACL3, ABCD3, ABHD1, ABHD15, ACAA1, ACAD, ACAD-12, ACBD6, Acetyl-CoA Synthetase, Acnat1, Acnat2, ACOT10, ACOT12, ACOT2, ACOT3, ACOT4, ACOT5, ACOT6, ACOT8, ACOT9, ACOX1, ACSBG1, ACSBG2, ACSF1, ACSF2, ACSF3, ACSF4, ACSL, ACSL, ACSL1, ACSL4, ACSL6, ACSM2B, ACSM5, ACSVL2, ACSVL4, ACSVL5, AMAC1L2, AWAT1, CIDE-C, CPS2, CPTI-L, DDHD1, DECR1, DECR2, dolichol kinase, DPPL2, EFO2, FABP12, FADS6, FAM57B, FAR1, FATP-1, FATP4, GDPD4, GLTP, Gm436, GNPAT, GOLGA7B, GPAM, GPAT2, GRAMD1A, GS2-like, HSDL2, iGb3, LARS2, LENG4, Lipid Biosynthesis, LIPM, Lipophilin A, LPAAT-α, LPAAT-δ, LPAAT-ε, LPAAT-γ, LPCAT1, LPD lipase, MBOAT2, Mecr, MLYCD, MSAP, MULK, PAM, PCYT2, PDH-E1β, PE, Peroxin 19, Pex7p, PHYHIPL, PLP2, SCP2, SEC14L1, SEC14L5, Seipin, SLMO2, SPTLC1, TFIIH p80, THEM5, TMEM170, TMEM195, TMEM41B, TMEM68, TTC39B, UHRF1BP1, VibH, ZDHHC, ZDHHC11B, ZDHHC14, ZDHHC19, ZDHHC4, ZDHHC6, and ZDHHC7.Activator of:
Acnat1, ACOT1, ACSVL1, ACSVL4, BTN1A1, Ces3b, Cypt2, DHODH, ELOVL5, PIG-K, SUCLG2, and ZDHHC23.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triacsin C Solution in DMSO, 100 µg | sc-200574 | 100 µg | $149.00 | |||
Triacsin C Solution in DMSO, 1 mg | sc-200574A | 1 mg | $826.00 |