Molecular structure of Triacsin C, lyophilized, CAS Number: 76896-80-5
Triacsin C, lyophilized (CAS 76896-80-5)
See product citations (3)
Application:
Triacsin C, lyophilized is almost completely inhibits de novo synthesis of triacylglycerol and phospholipid
CAS Number:
76896-80-5
Molecular Weight:
207.3
Molecular Formula:
C11H17N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Triacsin C can be isolated from Streptomyces aureofaciens culture. The compound is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) in intact cells and the nonspecific ACSL in cell sonicates (IC50=3.6-8.7 muM). Triacsin C may act to inhibit de novo synthesis of triacylglycerol, diacylglycerol, cholesterol esters, and phospholipids. The inhibitory effect of Triacsin C prevents degranulation by human neutrophils through superoxide anion generation inhibition, thus inhibiting neutrophil activity. Triacsin C may act by increasing methacholine-induced NO synthesis. The compound has also been reported to inhibit beta-cells by abolishing L-type Ca2+ CP (L-type Ca2+) channel modulation.
Triacsin C, lyophilized (CAS 76896-80-5) References
- Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate. | Shintani, M., et al. 2000. Metabolism. 49: 326-30. PMID: 10726909
- Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. | Muoio, DM., et al. 2000. Am J Physiol Endocrinol Metab. 279: E1366-73. PMID: 11093925
- Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. | Kim, JH., et al. 2001. J Biol Chem. 276: 24667-73. PMID: 11319222
- Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | Hayashi, M., et al. 1992. Biochem Biophys Res Commun. 188: 1280-5. PMID: 1445360
- Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells. | Iorio, E., et al. 2003. Biochim Biophys Acta. 1634: 1-14. PMID: 14563408
- Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver. | Vessey, DA., et al. 2004. J Biochem Mol Toxicol. 18: 100-6. PMID: 15122652
- Inhibiting long-chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells. | Weis, MT., et al. 2005. J Vasc Res. 42: 275-83. PMID: 15908751
- Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. | Matsuda, D., et al. 2008. J Antibiot (Tokyo). 61: 318-21. PMID: 18653998
- Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C. | Kaemmerer, E., et al. 2011. World J Gastroenterol. 17: 4883-9. PMID: 22171129
- Novel triacsin C analogs as potential antivirals against rotavirus infections. | Kim, Y., et al. 2012. Eur J Med Chem. 50: 311-8. PMID: 22365411
- Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism. | Eroglu, A., et al. 2016. J Biol Chem. 291: 4966-73. PMID: 26719343
- CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. | Wright, HJ., et al. 2017. Proc Natl Acad Sci U S A. 114: E6556-E6565. PMID: 28739932
- Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. | Dechandt, CRP., et al. 2017. J Bioenerg Biomembr. 49: 399-411. PMID: 28918598
- Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis. | Zhu, ZY., et al. 2022. Acta Pharmacol Sin. 43: 39-49. PMID: 33767380
- Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. | Xia, H., et al. 2021. Viruses. 13: PMID: 34960652
Inhibitor of:
ACSL, and Lipid Biosynthesis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Triacsin C, lyophilized, 200 µg | sc-477680 | 200 µg | $325.00 | |||
Triacsin C, lyophilized, 1 mg | sc-477680A | 1 mg | $900.00 |