Date published: 2025-11-24

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Triacetylresveratrol (CAS 42206-94-0)

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Alternate Names:
4-[(E)-2-(3,5-Diacetoxyphenyl)vinyl]phenyl acetate
Application:
Triacetylresveratrol is a resveratrol precursor and SIRT activator
CAS Number:
42206-94-0
Molecular Weight:
354.35
Molecular Formula:
C20H18O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triacetylresveratrol, a derivative of the well-known polyphenolic compound resveratrol, has garnered attention in scientific research for its potential biological activities and implications. Its mechanism of action involves modulation of various cellular pathways associated with inflammation, oxidative stress, and aging. Specifically, triacetylresveratrol exerts its effects by activating sirtuin enzymes, particularly SIRT1, which are implicated in regulating cellular metabolism, DNA repair, and longevity. Research investigations have demonstrated the ability of triacetylresveratrol to enhance sirtuin activity, leading to downstream effects such as improved mitochondrial function, increased antioxidant defenses, and enhanced stress resistance. Additionally, triacetylresveratrol has been explored for its potential anti-inflammatory properties, with studies indicating its ability to suppress pro-inflammatory cytokine production and inhibit NF-κB signaling. Moreover, triacetylresveratrol shows promise in modulating cellular senescence pathways, offering potential avenues for interventions in age-related diseases. Beyond its direct effects on cellular pathways, triacetylresveratrol has been investigated for its potential applications in various research areas, including aging biology, metabolic disorders, neurodegenerative diseases, and cancer. Its multifaceted mechanism of action and diverse research applications underscore triacetylresveratrol′s significance as a valuable tool for advancing our understanding of cellular physiology and exploring novel strategies.


Triacetylresveratrol (CAS 42206-94-0) References

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  3. High-throughput library screening identifies two novel NQO1 inducers in human lung cells.  |  Tan, XL., et al. 2012. Am J Respir Cell Mol Biol. 46: 365-71. PMID: 22021338
  4. Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis.  |  Park, J., et al. 2014. Arch Dermatol Res. 306: 475-87. PMID: 24414332
  5. Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.  |  Sengupta, R., et al. 2015. Oncotarget. 6: 18282-92. PMID: 26286961
  6. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells.  |  Duan, J., et al. 2016. Sci Rep. 6: 31672. PMID: 27539371
  7. Triacetyl resveratrol upregulates miRNA‑200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent.  |  Fu, J., et al. 2019. Int J Oncol. 54: 1306-1316. PMID: 30720134
  8. Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB.  |  Ding, L., et al. 2020. Biochem Pharmacol. 171: 113691. PMID: 31704236
  9. In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation.  |  Lee, Y., et al. 2021. J Innate Immun. 13: 94-106. PMID: 32937636
  10. Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti-Alzheimer potentials.  |  Zhang, M., et al. 2022. Biotechnol Appl Biochem.. PMID: 35933706
  11. The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts.  |  Gerasymchuk, M., et al. 2022. Int J Mol Sci. 23: PMID: 35955938
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triacetylresveratrol, 1 g

sc-358583
1 g
$216.00

Triacetylresveratrol, 5 g

sc-358583A
5 g
$772.00