Date published: 2026-4-5

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Tri-m-cresyl Phosphate (CAS 563-04-2)

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Alternate Names:
Phosphoric Acid Tri-m-cresyl Ester; Phosphoric Acid Tri-m-tolyl Ester; Tri-m-tolyl Phosphate
CAS Number:
563-04-2
Molecular Weight:
368.37
Molecular Formula:
C21H21O4P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tri-m-cresyl Phosphate (TMP), a member of the cresyl phosphate family, is an organophosphate compound that finds application in various fields. This colorless, oily liquid possesses a pungent odor and serves multiple purposes, functioning as a plasticizer, solvent, and insecticide. Moreover, Tri-m-cresyl Phosphate plays a role in industrial processes such as rubber and synthetic fiber production. Within the realm of scientific research, Tri-m-cresyl Phosphate is an invaluable asset, offering a plethora of applications. It serves as a model compound for investigating the impact of organophosphates on enzyme activity. Furthermore, Tri-m-cresyl Phosphate acts as a substrate for enzyme-catalyzed reactions, facilitating studies in this area. Additionally, Tri-m-cresyl Phosphate serves as a model compound for exploring the effects of organophosphates on the nervous system. It aids in the examination of organophosphates′ influence on cell membranes and their impact on membrane transport proteins. Functioning as an organophosphate, Tri-m-cresyl Phosphate acts as an inhibitor of acetylcholinesterase. It binds to the enzyme′s active site, hindering the breakdown of acetylcholine.


Tri-m-cresyl Phosphate (CAS 563-04-2) References

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  2. Occurrence and distribution of organophosphate triesters and diesters in sludge from sewage treatment plants of Beijing, China.  |  Gao, L., et al. 2016. Sci Total Environ. 544: 143-9. PMID: 26657359
  3. Effects of endocrine disrupting chemicals on estrogen receptor alpha and heat shock protein 60 gene expression in primary cultures of loggerhead sea turtle (Caretta caretta) erythrocytes.  |  Cocci, P., et al. 2017. Environ Res. 158: 616-624. PMID: 28719870
  4. Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells.  |  Pomatto, V., et al. 2018. J Steroid Biochem Mol Biol. 178: 322-332. PMID: 29410257
  5. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity.  |  Gu, Y., et al. 2018. Biochem Pharmacol. 152: 21-33. PMID: 29559311
  6. Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes: revealed by computational modeling (docking) and transcriptional regulation of signaling pathways.  |  Palermo, FA., et al. 2016. Toxicol Res (Camb). 5: 471-481. PMID: 30090361
  7. Threats of organophosphate esters (OPEs) in surface water to ecological system in Haihe River of China based on species sensitivity distribution model and assessment factor model.  |  Niu, Z., et al. 2019. Environ Sci Pollut Res Int. 26: 10854-10866. PMID: 30778928
  8. Biodegradation of tricresyl phosphate isomers by Brevibacillus brevis: Degradation pathway and metabolic mechanism.  |  Liu, Y., et al. 2019. Chemosphere. 232: 195-203. PMID: 31154180
  9. Measuring exposure of e-waste dismantlers in Dhaka Bangladesh to organophosphate esters and halogenated flame retardants using silicone wristbands and T-shirts.  |  Wang, Y., et al. 2020. Sci Total Environ. 720: 137480. PMID: 32146393
  10. Biodegradation of tricresyl phosphates isomers by a novel microbial consortium and the toxicity evaluation of its major products.  |  Yu, Y., et al. 2022. Sci Total Environ. 828: 154415. PMID: 35276152
  11. Dietary intake assessment of known and unknown organophosphate esters (OPEs) in foodstuffs via high-resolution mass spectrometry.  |  Bi, R. and Su, G. 2022. Sci Total Environ. 854: 158452. PMID: 36063922
  12. Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth.  |  Wang, H., et al. 2022. Environ Sci Technol. 56: 17018-17028. PMID: 36375127
  13. Occurrence of organophosphorus esters in outdoor air fine particulate matter and comprehensive assessment of human exposure: A global systematic review.  |  Azizi, S., et al. 2023. Environ Pollut. 318: 120895. PMID: 36529340
  14. Triphenyl phosphate allergy from spectacle frames.  |  Carlsen, L., et al. 1986. Contact Dermatitis. 15: 274-7. PMID: 3816190

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tri-m-cresyl Phosphate, 5 g

sc-473738
5 g
$149.00