TRF4 Antibody (2794C4a): sc-81637
- TRF4 Antibody (2794C4a) is a mouse monoclonal IgG1 TRF4 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to the C-terminal region of TRF4 of human origin
- recommended for detection of TRF4 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRF4 Antibody (2794C4a). This work is in progress.
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TRF4 Antibody (2794C4a) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRF4 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TRF4 antibody (2794C4a) is available as the non-conjugated format. TRF4, also known as topoisomerase-related function protein 4-1, POLS (polymerase sigma), POLK (polymerase κ), or LAK-1, plays a crucial role in DNA replication and repair, functioning as a member of the Y-family of translesion DNA polymerases. TRF4 (2794C4a) antibody recognizes a protein essential for facilitating DNA replication across damaged regions, thereby ensuring genomic stability. This function allows cells to bypass lesions that could otherwise stall replication forks, which can lead to genomic instability and contribute to various diseases, including cancer. TRF4 monoclonal antibody (2794C4a) targets a protein implicated in sister chromatid cohesion during DNA replication, ensuring proper attachment until anaphase for accurate chromosome segregation. TRF4 and associated exonucleases maintain genome integrity during cell division and DNA damage response.
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TRF4 Antibody (2794C4a) References:
- The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. | Walowsky, C., et al. 1999. J Biol Chem. 274: 7302-8. PMID: 10066793
- Pol kappa: A DNA polymerase required for sister chromatid cohesion. | Wang, Z., et al. 2000. Science. 289: 774-9. PMID: 10926539
- Evidence that replication fork components catalyze establishment of cohesion between sister chromatids. | Carson, DR. and Christman, MF. 2001. Proc Natl Acad Sci U S A. 98: 8270-5. PMID: 11459963
- Replication-related activities establish cohesion between sister chromatids. | Wang, Z. and Christman, MF. 2001. Cell Biochem Biophys. 35: 289-301. PMID: 11894848
- Eukaryotic DNA polymerases. | Hubscher, U., et al. 2002. Annu Rev Biochem. 71: 133-63. PMID: 12045093
- Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. | Choi, JY., et al. 2006. J Biol Chem. 281: 21062-21072. PMID: 16751196
- Mechanism of translesion synthesis past an equine estrogen-DNA adduct by Y-family DNA polymerases. | Yasui, M., et al. 2007. J Mol Biol. 371: 1151-62. PMID: 17603077
- 1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae. | Naganuma, M., et al. 2008. Bioorg Med Chem. 16: 2939-44. PMID: 18178092
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRF4 Antibody (2794C4a) | sc-81637 | 100 µg/ml | $339.00 |