Molecular structure of Trehalose, Dihydrate, CAS Number: 6138-23-4
Trehalose, Dihydrate (CAS 6138-23-4)
See product citations (6)
Alternate Names:
α-D-Glucopyranosyl-α-D-glucopyranoside
Application:
Trehalose, Dihydrate is an osmolyte, chemical chaperone, and inducer of autophagy
CAS Number:
6138-23-4
Purity:
98%
Molecular Weight:
378.33
Molecular Formula:
C12H22O11•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Trehalose, Dihydrate, is an osmolyte, a chemical chaperone and inducer of autophagy, that has been reported to protect cells against numerous environmental stresses. This compound contains many properties that allow it to stabilize partially unfolded protein molecules and inhibit protein aggregation. These properties include a low chemical reactivity, high glass transition temperature, existence of numerous polymorphs, nonreducing nature, and high affinity for water molecules. Additionally, Trehalose has been noted to bind to expanded polyglutamines and stabilize partially unfolded polyglutamine-containing proteins.
Trehalose, Dihydrate (CAS 6138-23-4) References
- Supercritical CO(2) fluid extraction of crystal water from trehalose dihydrate. Efficient production of form II (T(alpha)) phase. | Akao, K., et al. 2002. Carbohydr Res. 337: 1729-35. PMID: 12423951
- Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. | Tanaka, M., et al. 2004. Nat Med. 10: 148-54. PMID: 14730359
- A comparison of trehalose dihydrate and mannitol as stabilizing agents for dicalcium phosphate dihydrate based tablets. | Landín, M., et al. 2005. Drug Dev Ind Pharm. 31: 249-56. PMID: 15830720
- Dehydration of trehalose dihydrate at low relative humidity and ambient temperature. | Jones, MD., et al. 2006. Int J Pharm. 313: 87-98. PMID: 16504430
- Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. | Sarkar, S., et al. 2007. J Biol Chem. 282: 5641-52. PMID: 17182613
- Monitoring phase transformations in intact tablets of trehalose by FT-Raman spectroscopy. | Chakravarty, P., et al. 2009. AAPS PharmSciTech. 10: 1420-6. PMID: 19937407
- Trehalose and protein stability. | Jain, NK. and Roy, I. 2010. Curr Protoc Protein Sci. Chapter 4: Unit 4.9. PMID: 20155732
- Crystallization of trehalose in frozen solutions and its phase behavior during drying. | Sundaramurthi, P., et al. 2010. Pharm Res. 27: 2374-83. PMID: 20811935
- Influence of crystallizing and non-crystallizing cosolutes on trehalose crystallization during freeze-drying. | Sundaramurthi, P. and Suryanarayanan, R. 2010. Pharm Res. 27: 2384-93. PMID: 20824310
- Identification of primary free radicals in trehalose dihydrate single crystals X-irradiated at 10 K. | Tarpan, MA., et al. 2011. Phys Chem Chem Phys. 13: 11294-302. PMID: 21566842
- Estimation of crystallinity of trehalose dihydrate microspheres by usage of terahertz time-domain spectroscopy. | Takeuchi, I., et al. 2012. J Pharm Sci. 101: 3465-72. PMID: 22499332
- Spatial Distribution of Trehalose Dihydrate Crystallization in Tablets by X-ray Diffractometry. | Thakral, NK., et al. 2015. Mol Pharm. 12: 3766-75. PMID: 26332906
- Trehalose prevents myoglobin collapse and preserves its internal mobility. | Sastry, GM. and Agmon, N. 1997. Biochemistry. 36: 7097-108. PMID: 9188709
Activator of:
ZNF354A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trehalose, Dihydrate, 50 g | sc-202368 | 50 g | $147.00 | |||
Trehalose, Dihydrate, 500 g | sc-202368A | 500 g | $219.00 |