Date published: 2025-11-4

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Trazodone N-Oxide (CAS 55290-68-1)

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Alternate Names:
2-[3-[4-(3-Chlorophenyl)-1-oxido-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
Application:
Trazodone N-Oxide is a metabolite of Trazodone Hydrochloride
CAS Number:
55290-68-1
Molecular Weight:
387.86
Molecular Formula:
C19H22ClN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trazodone N-Oxide (TNO) is a metabolite of Trazodone Hydrochloride (sc-213097). It has been found to possess a wide range of biological activities, including neuroprotective, anti-inflammatory, anti-cancer, antioxidant, anti-apoptotic, anti-proliferative, and anti-viral properties. Trazodone N-Oxide ′s mechanism of action is not yet fully understood, but it is hypothesized to work by inhibiting specific enzymes like cyclooxygenase (COX) and lipoxygenase (LOX). Additionally, it has been found to inhibit certain proteins such as nuclear factor-κB (NF-κB) and signal transducer and activator of transcription (STAT).


Trazodone N-Oxide (CAS 55290-68-1) References

  1. Effects of trazodone on serotonin in the brain and platelets of the rat.  |  Garattini, S., et al. 1976. Biochem Pharmacol. 25: 13-6. PMID: 1252251

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trazodone N-Oxide, 5 mg

sc-213098
5 mg
$377.00