Date published: 2026-5-7

1-800-457-3801

SCBT Portrait Logo
Seach Input

Trazodone Hydrochloride (CAS 25332-39-2)

0.0(0)
Write a reviewAsk a question

Datasheets
Application:
Trazodone Hydrochloride is a serotonin antagonist and reuptake inhibitor
CAS Number:
25332-39-2
Molecular Weight:
408.32
Molecular Formula:
C19H22ClN5O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Trazodone Hydrochloride is a compound widely studied in the field of neuroscience research, especially in relation to its action on neurotransmitter systems. Focus is often placed on its influence on serotonin reuptake inhibition and the antagonism of certain serotonin receptor subtypes. Researchers examine Trazodone Hydrochloride′s binding profile across various neurotransmitter receptors and transporters to understand its spectrum of activity. Additionally, studies on Trazodone Hydrochloride investigate its impact on sleep architecture, given its effects on serotoninergic and adrenergic systems. The compound′s hydrochloride salt form enhances its solubility in aqueous solutions, which is beneficial for in vitro assays that explore its kinetic properties.


Trazodone Hydrochloride (CAS 25332-39-2) References

  1. Trazodone-induced palinopsia.  |  Hughes, MS. and Lessell, S. 1990. Arch Ophthalmol. 108: 399-400. PMID: 2310343
  2. Rediscovering trazodone for the treatment of major depressive disorder.  |  Fagiolini, A., et al. 2012. CNS Drugs. 26: 1033-49. PMID: 23192413
  3. Off-Label Trazodone Prescription: Evidence, Benefits and Risks.  |  Bossini, L., et al. 2015. Curr Pharm Des. 21: 3343-51. PMID: 26088119
  4. A review of trazodone use in psychiatric and medical conditions.  |  Khouzam, HR. 2017. Postgrad Med. 129: 140-148. PMID: 27744763
  5. Mutagenicity and recombinogenicity evaluation of bupropion hydrochloride and trazodone hydrochloride in somatic cells of Drosophila melanogaster.  |  Naves, MPC., et al. 2019. Food Chem Toxicol. 131: 110557. PMID: 31176925
  6. Clinical guidance for the use of trazodone in major depressive disorder and concomitant conditions: pharmacology and clinical practice.  |  Cuomo, A., et al. 2019. Riv Psichiatr. 54: 137-149. PMID: 31379379
  7. A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder.  |  Fagiolini, A., et al. 2020. Int Clin Psychopharmacol. 35: 137-146. PMID: 31972628
  8. The effects of trazodone on human cognition: a systematic review.  |  Gonçalo, AMG. and Vieira-Coelho, MA. 2021. Eur J Clin Pharmacol. 77: 1623-1637. PMID: 34097124
  9. Treatment of insomnia - effect of trazodone and hypnotics on sleep.  |  Wichniak, A., et al. 2021. Psychiatr Pol. 55: 743-755. PMID: 34994734
  10. The effect of preanaesthetic oral trazodone hydrochloride on the induction dose of propofol: a preliminary retrospective study.  |  Walters, K., et al. 2022. Vet Anaesth Analg. 49: 458-462. PMID: 35715325
  11. Attempting to Increase the Effectiveness of the Antidepressant Trazodone Hydrochloride Drug Using π-Acceptors.  |  Alsanie, WF., et al. 2022. Int J Environ Res Public Health. 19: PMID: 36141553
  12. Comparison of the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression.  |  Cui, Q. and Wei, W. 2023. J Pak Med Assoc. 73: 879-881. PMID: 37052005
  13. Trazodone hydrochloride: a wide spectrum antidepressant with a unique pharmacological profile. A review of its neurochemical effects, pharmacology, clinical efficacy, and toxicology.  |  Georgotas, A., et al. 1982. Pharmacotherapy. 2: 255-65. PMID: 6763207
  14. Antidepressant properties of trazodone.  |  Bryant, SG. and Ereshefsky, L. 1982. Clin Pharm. 1: 406-17. PMID: 6764164

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Trazodone Hydrochloride, 100 mg

sc-213097
100 mg
$194.00