TRAP-α Antibody (41-Q): sc-100314

TRAP-α Antibody (41-Q) is a mouse monoclonal IgG1 antibody that detects TRAP-α in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TRAP-α, also known as SSR1 or SSR-α, is a crucial component of the translocon-associated protein complex, which plays a vital role in the endoplasmic reticulum (ER) by regulating the retention of ER resident proteins. TRAP-α is primarily located in the ER membrane, where TRAP-α interacts with the Sec61 translocon, the major complex responsible for mediating protein translocation across the ER membrane. Proper functioning of TRAP-α is essential for maintaining cellular homeostasis, as TRAP-α ensures that proteins destined for the ER are correctly processed and retained, preventing the accumulation of misfolded proteins that can lead to ER stress and subsequent cellular dysfunction. Additionally, TRAP-α is involved in the ER-associated degradation pathway, which is activated in response to ER stress through the XBP-1/IRE1α signaling pathway, highlighting TRAP-α′s importance in cellular stress responses. With TRAP-α′s ability to facilitate critical processes within the ER, TRAP-α is a key player in maintaining protein quality control and overall cellular health.

The preferred TRAP-α antibody is TRAP-α Antibody (C-8): sc-373916.