(±)-trans-U-50488 methanesulfonate salt (CAS 83913-05-7)
QUICK LINKS
(±)-trans-U-50488 methanesulfonate salt acts as a selective κ-opioid receptor agonist. It functions by binding to and activating the κ-opioid receptors, which are G protein-coupled receptors located on the surface of cells. Upon activation, these receptors modulate the activity of intracellular signaling pathways, leading to the inhibition of neurotransmitter release. This inhibition results in the modulation of neuronal excitability and synaptic transmission in the central and peripheral nervous systems. (±)-trans-U-50488 methanesulfonate salt′s mechanism of action involves the specific interaction with the κ-opioid receptors, leading to downstream effects on cellular signaling and neuronal function. This interaction at the molecular level contributes to the compound′s functional role in experimental studies investigating the pharmacology and neurobiology of opioid receptors.
(±)-trans-U-50488 methanesulfonate salt (CAS 83913-05-7) References
- Mu but not delta and kappa opioid receptor involvement in ventrolateral orbital cortex opioid-evoked antinociception in formalin test rats. | Xie, YF., et al. 2004. Neuroscience. 126: 717-26. PMID: 15183520
- Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines. | Takabuchi, S., et al. 2005. J Anesth. 19: 263-5. PMID: 16032459
- Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner. | Daijo, H., et al. 2011. Eur J Pharmacol. 667: 144-52. PMID: 21703258
- Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats. | Russell, SE., et al. 2014. Biol Psychiatry. 76: 213-22. PMID: 24090794
- Opioid subtype- and cell-type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex. | Yokota, E., et al. 2016. Neuroscience. 339: 478-490. PMID: 27725218
- Females are less sensitive than males to the motivational- and dopamine-suppressing effects of kappa opioid receptor activation. | Conway, SM., et al. 2019. Neuropharmacology. 146: 231-241. PMID: 30528327
- The search for the 'next' euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning. | Sharma, KK., et al. 2019. Forensic Toxicol. 37: 1-16. PMID: 30636980
- Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats. | Page, S., et al. 2019. Int J Neuropsychopharmacol. 22: 735-745. PMID: 31613314
- Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling. | Jacobson, ML., et al. 2020. Neuropharmacology. 177: 108254. PMID: 32726598
- Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer. | Silva, VL., et al. 2021. Cell Death Dis. 12: 395. PMID: 33854036
- Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids. | Erwin, LL., et al. 2021. Pharmacol Biochem Behav. 207: 173218. PMID: 34118232
- Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study. | Karnošová, A., et al. 2021. Int J Mol Sci. 22: PMID: 34445614
- Intrathecal morphine exacerbates paresis with increasing muscle tone of hindlimbs in rats with mild thoracic spinal cord injury but without damage of lumbar α-motoneurons. | Kawakami, K., et al. 2022. PLoS One. 17: e0273095. PMID: 35969631
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-trans-U-50488 methanesulfonate salt, 10 mg | sc-301928 | 10 mg | $146.00 | |||
(±)-trans-U-50488 methanesulfonate salt, 50 mg | sc-301928A | 50 mg | $448.00 |