Molecular structure of trans-HR22C16, CAS Number: 462630-41-7
trans-HR22C16 (CAS 462630-41-7)
Application:
trans-HR22C16 is an inhibitor of mitosis not interacting with tubulin
CAS Number:
462630-41-7
Purity:
≥95%
Molecular Weight:
389.5
Molecular Formula:
C23H23N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
trans-HR22C16 is a cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=800nM) by binding to the mitotic kinesin Eg5. trans-HR22C16 is an impressive inhibitor of the mitotic kinesin Eg5 that possesses remarkable potency, selectivity, and the ability to permeate cells. By effectively targeting Eg5, this inhibitor, with an IC50 value of 800nM, effectively disrupts the process of mitosis.
trans-HR22C16 (CAS 462630-41-7) References
- HR22C16: a potent small-molecule probe for the dynamics of cell division. | Hotha, S., et al. 2003. Angew Chem Int Ed Engl. 42: 2379-82. PMID: 12783501
- Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. | Even-Ram, S., et al. 2007. Nat Cell Biol. 9: 299-309. PMID: 17310241
- Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. | Katsuki, Y., et al. 2008. Cancer Sci. 99: 1539-45. PMID: 18754864
- Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data. | Sheff, JG., et al. 2017. Mol Cell Proteomics. 16: 428-437. PMID: 28062800
Inhibitor of:
Eg5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans-HR22C16, 1 mg | sc-202842 | 1 mg | $128.00 |