Date published: 2025-10-2

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(−)-trans-Caryophyllene (CAS 87-44-5)

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Alternate Names:
β-caryophyllene
Application:
(−)-trans-Caryophyllene is a phytochemical compound that is a constituent of many essential oils
CAS Number:
87-44-5
Purity:
≥98%
Molecular Weight:
204.35
Molecular Formula:
C15H24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-trans-Caryophyllene is a phytochemical compound that is a constituent of many essential oils. (−)-trans-Caryophyllene is a naturally occurring sesquiterpene found in various plants, including black pepper, cloves, and cannabis. It is a bicyclic molecule with a characteristic spicy and woody aroma. (−)-trans-Caryophyllene is known for its potential therapeutic properties, including anti-inflammatory, analgesic, and neuroprotective effects.


(−)-trans-Caryophyllene (CAS 87-44-5) References

  1. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.  |  Fernandes, ES., et al. 2007. Eur J Pharmacol. 569: 228-36. PMID: 17559833
  2. Terpenes Combinations Inhibit Biofilm Formation in Staphyloccocus aureus by Interfering with Initial Adhesion.  |  Salinas, C., et al. 2022. Microorganisms. 10: PMID: 36013945
  3. Effects of β -caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction.  |  Asth, L., et al. 2023. Curr Neuropharmacol. 21: 213-218. PMID: 36173065
  4. Development of a GC/Q-ToF-MS Method Coupled with Headspace Solid-Phase Microextraction to Evaluate the In Vitro Metabolism of β-Caryophyllene.  |  Lee, J., et al. 2022. Molecules. 27: PMID: 36364270
  5. Anti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts.  |  Viveiros, MMH., et al. 2022. Int J Ophthalmol. 15: 1903-1907. PMID: 36536965
  6. β-caryophyllene, a cannabinoid receptor 2 agonist, decreases the motivational salience and conditioning place preference for palatable food in female mice.  |  Dos Santos Barbosa, LA., et al. 2023. Addict Biol. 28: e13249. PMID: 36577722
  7. Composition, Antibacterial Efficacy, and Anticancer Activity of Essential Oil Extracted from Psidium guajava (L.) Leaves.  |  Alam, A., et al. 2023. Plants (Basel). 12: PMID: 36678958
  8. Investigation of β-caryophyllene as terpene penetration enhancer: Role of stratum corneum retention.  |  Tang, Q., et al. 2023. Eur J Pharm Sci. 183: 106401. PMID: 36750147
  9. Essential Oils from Origanum vulgare subsp. virens (Hoffmanns. & Link) Ietsw. Grown in Portugal: Chemical Diversity and Relevance of Chemical Descriptors.  |  Machado, AM., et al. 2023. Plants (Basel). 12: PMID: 36771704
  10. Essential Oil Composition of Seven Bulgarian Hypericum Species and Its Potential as a Biopesticide.  |  Semerdjieva, I., et al. 2023. Plants (Basel). 12: PMID: 36840272
  11. Chemistry and Bioactivity of Croton Essential Oils: Literature Survey and Croton hirtus from Vietnam.  |  Luu-Dam, NA., et al. 2023. Molecules. 28: PMID: 36903605
  12. Effects of Piper nigrum L. Fruit Essential Oil Toxicity against Stable Fly (Diptera: Muscidae).  |  Weluwanarak, T., et al. 2023. Plants (Basel). 12: PMID: 36903904
  13. In Vitro Antiviral Potential, Antioxidant, and Chemical Composition of Clove (Syzygium aromaticum) Essential Oil.  |  Kiki, MJ. 2023. Molecules. 28: PMID: 36985392
  14. Volatile Metabolites of Piper eriopodon (Miq.) C.DC. from Northern Region of Colombia and Assessment of In Vitro Bioactivities of the Leaf Essential Oil.  |  Muñoz-Acevedo, A., et al. 2023. Molecules. 28: PMID: 36985563
  15. Molecular Structure, Electronic Properties, Reactivity (ELF, LOL, and Fukui), and NCI-RDG Studies of the Binary Mixture of Water and Essential Oil of Phlomis bruguieri.  |  Akman, F., et al. 2023. Molecules. 28: PMID: 36985656

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-trans-Caryophyllene, 1 ml

sc-251281
1 ml
$79.00

(−)-trans-Caryophyllene, 5 ml

sc-251281A
5 ml
$157.00

(−)-trans-Caryophyllene, 25 ml

sc-251281B
25 ml
$437.00

(−)-trans-Caryophyllene, 1 L

sc-251281C
1 L
$2861.00