Molecular structure of trans-Anethole, CAS Number: 4180-23-8
trans-Anethole (CAS 4180-23-8)
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CAS Number:
4180-23-8
Molecular Weight:
148.20
Molecular Formula:
C10H12O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
trans-Anethole is a naturally occurring phenylpropene derivative that is estrogenic at lower concentrations and cytotoxic at higher concentrations in cancer cell lines. The cytotoxicity is related to the metabolism of trans-anethole to 4-hydroxy-1-propenylbenzene. trans-Anethole, a naturally occurring aromatic compound, can be found in various plants and spices like anise, fennel, and star anise. Its applications are diverse, being widely utilized as a flavoring agent in food and beverages, and as an ingredient in fragrances and cosmetics. While much has been discovered about trans-Anethole, its exact mechanism of action remains partially mysterious. However, research suggests that it may function by inhibiting specific enzymes responsible for reducing the production of inflammatory cytokines.
trans-Anethole (CAS 4180-23-8) References
- Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. | Ryu, S., et al. 2014. Neurol Sci. 35: 1541-7. PMID: 24777545
- Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats. | Seo, E., et al. 2018. Biomed Pharmacother. 102: 249-253. PMID: 29567537
- trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel. | Memon, T., et al. 2019. Mol Pharmacol. 95: 433-441. PMID: 30679204
- trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells. | Pandit, K., et al. 2021. Nutr Cancer. 73: 1727-1745. PMID: 32781844
- Trans-anethole attenuates diet-induced nonalcoholic steatohepatitis through suppressing TGF-β-mediated fibrosis. | Zhang, C., et al. 2022. Clin Res Hepatol Gastroenterol. 46: 101833. PMID: 34785385
- Trans-Anethole Alleviates Subclinical Necro-Haemorrhagic Enteritis-Induced Intestinal Barrier Dysfunction and Intestinal Inflammation in Broilers. | Yu, C., et al. 2022. Front Microbiol. 13: 831882. PMID: 35387091
- Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers. | Yu, C., et al. 2022. Front Vet Sci. 9: 877066. PMID: 35518639
- Anticonvulsant Activity of trans-Anethole in Mice. | da Guedes, E., et al. 2022. Biomed Res Int. 2022: 9902905. PMID: 35607305
- Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells. | Yu, C., et al. 2022. Int Immunopharmacol. 108: 108872. PMID: 35617845
- Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway. | Tong, Y., et al. 2022. Poult Sci. 101: 101962. PMID: 35690001
- Anti-depressive-like effect of monoterpene trans-anethole via monoaminergic pathways. | Hassanzadeh, SA., et al. 2022. Saudi J Biol Sci. 29: 3255-3261. PMID: 35844399
- Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation. | Chang, W., et al. 2022. Pharmaceutics. 14: PMID: 35890317
- Staphyloxanthin inhibitory potential of trans-anethole: A preliminary study. | Kwiatkowski, P., et al. 2023. Biomed Pharmacother. 158: 114153. PMID: 36566523
- Immunomodulatory effects of trans-anethole-treated Staphylococcus aureus Newman strain. | Kwiatkowski, P., et al. 2023. Sci Rep. 13: 6881. PMID: 37106063
- Effect of Trans-Anethole on Gene Expression of Steroidogenic Enzymes in the Ovary of Polycystic Ovary Syndrome Model Rate: | Asadian, M., et al. 2022. Galen Med J. 11: e2219. PMID: 37200684
Inhibitor of:
Olfr102, Olfr1040, Olfr311, Olfr412, Olfr421, Olfr596, Olfr665, and OR4K2.Activator of:
Olfr1002, Olfr1015, Olfr103, Olfr1045, Olfr1051, Olfr1062, Olfr1065, Olfr1098, Olfr1101, Olfr308, Olfr311, Olfr318, Olfr330, Olfr341, Olfr371, Olfr417, Olfr481, Olfr497, Olfr502, Olfr504, Olfr536, Olfr541, Olfr550, Olfr551, Olfr556, Olfr605, Olfr607, Olfr610, Olfr612, Olfr618, Olfr654, Olfr659, Olfr66, Olfr661, Olfr663, Olfr666, Olfr667, Olfr668, Olfr740, Olfr832, Olfr845, Olfr898, Olfr972, Olfr983, OR10W1, OR11H6, OR13J1, OR1A1, OR2T1, and OR4Q3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans-Anethole, 1 ml | sc-253727 | 1 ml | $28.00 |