Date published: 2026-4-5

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trans-Aconitic acid (CAS 4023-65-8)

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Application:
trans-Aconitic acid is an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes
CAS Number:
4023-65-8
Purity:
≥97%
Molecular Weight:
174.11
Molecular Formula:
C6H6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trans-Aconitic acid (TA) is a naturally occurring organic acid present in both plants and animals. It is considered a structural isomer of citric acid and serves as a vital constituent of the Krebs cycle. With its pivotal role in the metabolism of carbohydrates, proteins, and lipids, Trans-Aconitic acid functions as a significant intermediate in these metabolic processes. trans-Aconitic acid is an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes.


trans-Aconitic acid (CAS 4023-65-8) References

  1. Metabolism of trans-Aconitic Acid in Maize : II. Regulatory Properties of Two Compartmented Forms of Citrate Dehydrase.  |  Brauer, D. and Teel, MR. 1982. Plant Physiol. 70: 723-7. PMID: 16662564
  2. Isolation of trans-Aconitic Acid from the Moss Mnium affine.  |  Tachibana, S. and Meeuse, BJ. 1960. Science. 132: 1671. PMID: 17747267
  3. Trans-Aconitic Acid in Range Grasses in Early Spring.  |  Burau, R. and Stout, PR. 1965. Science. 150: 766-7. PMID: 17835250
  4. Quantitation of trans-aconitic acid in different stages of the sugar-manufacturing process.  |  Montoya, G., et al. 2014. J Agric Food Chem. 62: 8314-8. PMID: 25098840
  5. Enzymatic characterization and gene identification of aconitate isomerase, an enzyme involved in assimilation of trans-aconitic acid, from Pseudomonas sp. WU-0701.  |  Yuhara, K., et al. 2015. FEBS J. 282: 4257-67. PMID: 26293748
  6. Contribution of trans-aconitic acid to DPPH scavenging ability in different media.  |  Piang-Siong, W., et al. 2017. Food Chem. 214: 447-452. PMID: 27507497
  7. Genetic and Biochemical Characterization of a Gene Operon for trans-Aconitic Acid, a Novel Nematicide from Bacillus thuringiensis.  |  Du, C., et al. 2017. J Biol Chem. 292: 3517-3530. PMID: 28087696
  8. Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis.  |  Oliveira, DP., et al. 2018. Biomed Pharmacother. 99: 87-95. PMID: 29329035
  9. Encapsulation of trans-aconitic acid in mucoadhesive microspheres prolongs the anti-inflammatory effect in LPS-induced acute arthritis.  |  Pinto de Oliveira, D., et al. 2018. Eur J Pharm Sci. 119: 112-120. PMID: 29627623
  10. Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.  |  Bortolo, TDSC., et al. 2018. Plant Physiol Biochem. 132: 490-496. PMID: 30292981
  11. Constitutive production of aconitate isomerase by Pseudomonas sp. WU-0701 in relation to trans-aconitic acid assimilation.  |  Takiguchi, A., et al. 2021. J Biosci Bioeng. 131: 47-52. PMID: 32994133
  12. Effect of tricarballylic acid, a nonmetabolizable rumen fermentation product of trans-aconitic acid, on Mg, Ca and Zn utilization of rats.  |  Schwartz, R., et al. 1988. J Nutr. 118: 183-8. PMID: 3339476
  13. Microbial production of trans-aconitic acid.  |  Geng, C., et al. 2023. Metab Eng.. PMID: 37315711
  14. Fluorometric determination of carbodiimides with trans-aconitic acid.  |  Chen, SC. 1983. Anal Biochem. 132: 272-5. PMID: 6625167

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

trans-Aconitic acid, 25 g

sc-255679
25 g
$57.00