Molecular structure of trans-4-Hydroxy-L-proline, CAS Number: 51-35-4
trans-4-Hydroxy-L-proline (CAS 51-35-4)
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Alternate Names:
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Application:
trans-4-Hydroxy-L-proline is a versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins
CAS Number:
51-35-4
Purity:
≥98%
Molecular Weight:
131.13
Molecular Formula:
C5H9NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
trans-4-Hydroxy-L-proline is extensively used in biochemical and structural biology research, particularly in studies focusing on collagen structure and stability. This compound is a key player in understanding the post-translational modifications that occur in collagen and other proline-rich proteins. Researchers utilize trans-4-Hydroxy-L-proline to investigate its role in the thermal stability and mechanical properties of collagen fibers, which are essential for tissue integrity and function. Additionally, this hydroxyproline variant is used in the study of the biosynthesis pathways of hydroxyproline and its implications in connective tissue disorders.
trans-4-Hydroxy-L-proline (CAS 51-35-4) References
- Characterization of a Novel cis-3-Hydroxy-l-Proline Dehydratase and a trans-3-Hydroxy-l-Proline Dehydratase from Bacteria. | Watanabe, S., et al. 2017. J Bacteriol. 199: PMID: 28559297
- Efficient production of trans-4-Hydroxy-l-proline from glucose by metabolic engineering of recombinant Escherichia coli. | Zhang, HL., et al. 2018. Lett Appl Microbiol. 66: 400-408. PMID: 29432647
- Efficient production of trans-4-hydroxy-l-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli. | Wang, XC., et al. 2018. J Biosci Bioeng. 126: 470-477. PMID: 29805115
- Development, validation, and application of a liquid chromatography-tandem mass spectrometry method for quantitative determination of trans-4-hydroxy-l-proline concentration in the serum of dogs with chronic hepatitis. | Lawrence, YA., et al. 2019. Am J Vet Res. 80: 434-440. PMID: 31034276
- Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form. | Ferraris, DM., et al. 2019. Biochem Biophys Res Commun. 516: 189-195. PMID: 31208721
- Chassis engineering of Escherichia coli for trans-4-hydroxy-l-proline production. | Chen, X., et al. 2021. Microb Biotechnol. 14: 392-402. PMID: 32396278
- Enzymatic production of trans-4-hydroxy-l-proline by proline 4-hydroxylase. | Chen, X., et al. 2021. Microb Biotechnol. 14: 479-487. PMID: 32618422
- Isolation of a Bacillus cereus strain HBL-AI and its application for production of Trans-4-hydroxy-l-proline. | Wang, XM., et al. 2021. Lett Appl Microbiol. 72: 53-59. PMID: 32955742
- Metabolic engineering strategy for synthetizing trans-4-hydroxy-L-proline in microorganisms. | Zhang, Z., et al. 2021. Microb Cell Fact. 20: 87. PMID: 33882914
- Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline. | Bogner, AN., et al. 2021. Protein Sci. 30: 1714-1722. PMID: 34048122
- The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia. | Reed, AD., et al. 2022. mSphere. 7: e0092621. PMID: 35350846
- Modular reconstruction and optimization of the trans-4-hydroxy-L-proline synthesis pathway in Escherichia coli. | Zhang, Z., et al. 2022. Microb Cell Fact. 21: 159. PMID: 35953819
- [Advances on microbial synthesis of L-proline and trans-4-hydroxy-L-proline]. | Hu, X., et al. 2022. Sheng Wu Gong Cheng Xue Bao. 38: 4498-4519. PMID: 36593190
- Biosynthesis of trans-4-hydroxy-L-proline by Streptomyces griseoviridus. | Katz, E., et al. 1979. J Biol Chem. 254: 6684-90. PMID: 447743
- Studies on bound trans-4-hydroxy-L-proline in sandal (Santalum album L.). | Kuttan, R. and Radhakrishnan, AN. 1970. Biochem J. 119: 651-7. PMID: 5493503
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans-4-Hydroxy-L-proline, 25 g | sc-208462 | 25 g | $69.00 | |||
trans-4-Hydroxy-L-proline, 100 g | sc-208462A | 100 g | $222.00 |