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trans-3'-Hydroxy Cotinine O-β-D-Glucuronide is a nicotine metabolite known to be carcinogenic.
1. Le Marchand, L., et al., 1998. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer research. 58(21): 4858-63. PMID: 9809991
2. Minna, John D., et al., 2003. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. The Journal of clinical investigation. 111(1): 31-3. PMID: 12511585
3. Bierut, Laura Jean., et al., 2007. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human molecular genetics. 16(1): 24-35. PMID: 17158188
4. Thorgeirsson, Thorgeir E., et al., 2008. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 452(7187): 638-42. PMID: 18385739
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