trans-3′-Hydroxy Cotinine O-β-D-Glucuronide CAS: 132929-88-5
MF: C16H20N2O8
MW: 368.34
A nicotine metabolite known to be carcinogenic.

trans-3′-Hydroxy Cotinine O-β-D-Glucuronide (CAS 132929-88-5)

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Synonym: (3R,5S)-1-Methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl β-D-Glucopyranosiduronic Acid; trans-3′-Hydroxycotinine-O-glucuronide
Application: A nicotine metabolite known to be carcinogenic
CAS Number: 132929-88-5
Molecular Weight: 368.34
Molecular Formula: C16H20N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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trans-3'-Hydroxy Cotinine O-β-D-Glucuronide is a nicotine metabolite known to be carcinogenic.


1. Le Marchand, L., et al., 1998. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer research. 58(21): 4858-63. PMID: 9809991
2. Minna, John D., et al., 2003. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. The Journal of clinical investigation. 111(1): 31-3. PMID: 12511585
3. Bierut, Laura Jean., et al., 2007. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human molecular genetics. 16(1): 24-35. PMID: 17158188
4. Thorgeirsson, Thorgeir E., et al., 2008. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 452(7187): 638-42. PMID: 18385739

Physical State :
Solubility :
Soluble in water, and methanol.
Storage :
Store at -20° C
Melting Point :
>160° C
Boiling Point :
~699.2° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

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