1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium (CAS 132929-88-5 free base)
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1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium, also know as trans-3′-Hydroxy Cotinine O-β-D-Glucuronide, is a nicotine metabolite known to be carcinogenic. Studies suggest it′s function as an agonist at nicotinic acetylcholine receptors. The addition of a hydroxy group and its conjugation with β-D-glucuronic acid enhances its solubility in water, making it particularly useful in studies related to environmental and biochemical processes. Its structure, featuring a glucuronic acid moiety linked to cotinine, makes it an interesting subject for research in the field of analytical chemistry, especially in the development of assays and analytical techniques for the detection and quantification of nicotine metabolites. This is in environmental monitoring, where understanding the presence and concentration of nicotine-related compounds can provide insights into pollution sources and their impacts on ecosystems.
1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium (CAS 132929-88-5 free base) References
- Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. | Minna, JD. 2003. J Clin Invest. 111: 31-3. PMID: 12511585
- Novel genes identified in a high-density genome wide association study for nicotine dependence. | Bierut, LJ., et al. 2007. Hum Mol Genet. 16: 24-35. PMID: 17158188
- A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. | Thorgeirsson, TE., et al. 2008. Nature. 452: 638-642. PMID: 18385739
- Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. | Le Marchand, L., et al. 1998. Cancer Res. 58: 4858-63. PMID: 9809991
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-O-(trans-3-Hydroxycotinine)-b-D-glucuronide ammonium, 1 mg | sc-222363 | 1 mg | $734.00 |