Molecular structure of trans-(1S,3R)-ACPD
trans-(1S,3R)-ACPD (CAS 111900-32-4)
Alternate Names:
trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid
Application:
trans-(1S,3R)-ACPD is a rigid glutamate analog and mGluR activator
CAS Number:
111900-32-4
Molecular Weight:
173.17
Molecular Formula:
C7H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Trans-(1S,3R)-ACPD, or trans-1-amino-1,3-dicarboxycyclopentane, is a rigid analog of the neurotransmitter glutamate and a selective agonist of mGluR (metabotropic glutamate receptors). Trans-(1S,3R)-ACPD excites and modulates neuronal activity comparable to the actions of α-kainic acid, producing depolarization of the neuron and subsequent excitation. Seizure and neuronal injury are reported with exposure to Trans-(1S,3R)-ACPD, mediated by mobilization of intracellular calcium stores. Trans-(1S,3R)-ACPD is also described to stimulate phosphoinositide hydrolysis. Trans-(1S,3R)-ACPD is the active isomer of (±)-trans-ACPD preparations. Trans-(1S,3R)-ACPD is an activator of mGluR-2, mGluR-5, mGluR-6.
trans-(1S,3R)-ACPD (CAS 111900-32-4) References
- Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat. | Bhatnagar, T., et al. 1999. Brain Res. 822: 192-9. PMID: 10082896
- 2-Chloro-adenosine induces a glutamate-dependent calcium response in C2C12 myotubes. | Frank, C., et al. 2000. Biochem Biophys Res Commun. 277: 546-51. PMID: 11061991
- G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. | Straiker, AJ., et al. 2002. J Neurosci. 22: 2460-8. PMID: 11923410
- A fundamental oscillatory state of isolated rodent hippocampus. | Wu, C., et al. 2002. J Physiol. 540: 509-27. PMID: 11956340
- Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids. | Meyer, U., et al. 2005. Chirality. 17: 99-107. PMID: 15660439
- Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology. | Scandroglio, P., et al. 2010. J Biomol Screen. 15: 1238-47. PMID: 20811068
- Pregabalin is a potent and selective ligand for α(2)Δ-1 and α(2)Δ-2 calcium channel subunits. | Li, Z., et al. 2011. Eur J Pharmacol. 667: 80-90. PMID: 21651903
- Glutamate receptor-mediated calcium surges in neurons derived from P19 cells. | Morley, P., et al. 1995. J Neurochem. 65: 1093-9. PMID: 7643087
- An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons. | Durkin, JP., et al. 1996. J Neurochem. 66: 951-62. PMID: 8769854
- Activation of Ca2+-dependent currents in dorsal root ganglion neurons by metabotropic glutamate receptors and cyclic ADP-ribose precursors. | Crawford, JH., et al. 1997. J Neurophysiol. 77: 2573-84. PMID: 9163377
- G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. | Lüscher, C., et al. 1997. Neuron. 19: 687-95. PMID: 9331358
- AMPA receptor-mediated regulation of a Gi-protein in cortical neurons. | Wang, Y., et al. 1997. Nature. 389: 502-4. PMID: 9333240
- Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade. | Dixon, DB. and Copenhagen, DR. 1997. J Neurosci. 17: 8945-54. PMID: 9364042
- Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission. | Birnstiel, S., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 611-8. PMID: 9402041
- Glutamate-stimulated production of inositol phosphates is mediated by Ca2+ influx in oligodendrocyte progenitors. | Liu, HN., et al. 1997. Eur J Pharmacol. 338: 277-87. PMID: 9424022
Activator of:
mGluR-2, mGluR-5, and mGluR-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans-(1S,3R)-ACPD, 5 mg | sc-391145 | 5 mg | $197.00 |