Date published: 2026-4-24

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trans-1-Acetyl-4-hydroxy-L-proline (CAS 33996-33-7)

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Alternate Names:
Acetyl-L-4-hydroxyproline; Nα-Acetyl-L-4-trans-hydroxyproline; N-Acetyl-L-hydroxyproline
CAS Number:
33996-33-7
Molecular Weight:
173.17
Molecular Formula:
C7H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Trans-1-Acetyl-4-hydroxy-L-proline is a compound that is recognized for its role in research focused on biochemical and physiological processes. Scientists often utilize this chemical in studies investigating the stability and conformation of peptides and proteins, as the hydroxyproline component is a key factor in the triple-helix formation of collagen. In plant biology, trans-1-Acetyl-4-hydroxy-L-proline is used to explore its effects on plant growth and development, as it is an analogue of proline that can interfere with proline metabolism. Additionally, research involving osmotic stress responses frequently includes this compound, since it can mimic the accumulation of proline which occurs in various organisms under stress conditions. The chemical is also involved in the synthesis of complex naturally occurring compounds, serving as a building block in the construction of various secondary metabolites during organic synthesis studies.


trans-1-Acetyl-4-hydroxy-L-proline (CAS 33996-33-7) References

  1. Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.  |  Cai, R., et al. 2019. Nat Neurosci. 22: 317-327. PMID: 30598527
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  3. Can Developments in Tissue Optical Clearing Aid Super-Resolution Microscopy Imaging?  |  Matryba, P., et al. 2021. Int J Mol Sci. 22: PMID: 34201632
  4. Comparative Analyses of Clearing Efficacies of Tissue Clearing Protocols by Using a Punching Assisted Clarity Analysis.  |  Woo, J., et al. 2021. Front Bioeng Biotechnol. 9: 784626. PMID: 35155401
  5. Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.  |  Empl, L., et al. 2022. Nat Commun. 13: 2659. PMID: 35551446
  6. Scalable tissue labeling and clearing of intact human organs.  |  Mai, H., et al. 2022. Nat Protoc. 17: 2188-2215. PMID: 35859136
  7. Spatial proteomics in three-dimensional intact specimens.  |  Bhatia, HS., et al. 2022. Cell. 185: 5040-5058.e19. PMID: 36563667

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

trans-1-Acetyl-4-hydroxy-L-proline, 5 g

sc-237135
5 g
$67.00