Molecular structure of (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane, CAS Number: 257641-01-3
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (CAS 257641-01-3)
Alternate Names:
Vectrase P; 2-sulfanyl-N-[2-[(2-sulfanylacetyl)amino]cyclohexyl]acetamide
Application:
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a useful disulfide-containing protein refolding agent
CAS Number:
257641-01-3
Purity:
98%
Molecular Weight:
262.39
Molecular Formula:
C10H18N2O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a cyclohexane compound substituted with two mercaptoacetamido groups. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane has been described to effectively accelerate oxidative protein folding through interaction with thiol-disulfide exchange reactions, and was demonstrated to be particularly effective in refolding disulfide-containing proteins.
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (CAS 257641-01-3) References
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- Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions. | Willis, MS., et al. 2005. Protein Sci. 14: 1818-26. PMID: 15937284
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- Non-redox-active small-molecules can accelerate oxidative protein folding by novel mechanisms. | Fink, M., et al. 2008. Biophys Chem. 132: 104-9. PMID: 18045767
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- Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis. | Browne, EC., et al. 2016. Bioorg Med Chem. 24: 1520-7. PMID: 26935939
- The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models. | Parakh, S., et al. 2020. iScience. 23: 101097. PMID: 32446203
- Peptide disulfides CGC and RKCGC facilitate oxidative protein refolding | Guo-Zhen Wang, Xiaoyan Dong, Yan Sun. 2011. Biochemical Engineering Journal. Volume 55, Issue 3: 169-175.
- Peptide disulfide RKCGCFF facilitates oxidative protein refolding by mimicking protein disulfide isomerase | Hu Liu, Xiao-Yan Dong, Yan Sun. 2013. Biochemical Engineering Journal. 79: 29-32.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane, 100 mg | sc-213078 | 100 mg | $372.00 |