Molecular structure of Trandolapril, CAS Number: 87679-37-6
Trandolapril (CAS 87679-37-6)
Alternate Names:
2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid, Mavik
Application:
Trandolapril is an angiotensin-converting enzyme (ACE) inhibitor
CAS Number:
87679-37-6
Molecular Weight:
430.5
Molecular Formula:
C24H34N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Trandolapril is an inhibitor of ACE (angiotensin-converting enzyme), which converts angiotensin I into angiotensin II, a potent vasoconstrictor. Preventing this conversion reduces levels of angiotensin II, thus causing vasodilation and an increase in capillary blood volume. This compound shows a high degree of lipophilicity.
Trandolapril (CAS 87679-37-6) References
- Trandolapril: a newer angiotensin-converting enzyme inhibitor. | Guay, DR. 2003. Clin Ther. 25: 713-75. PMID: 12852701
- Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. | Chobanian, AV., et al. 1992. Hypertension. 20: 473-7. PMID: 1398882
- Angiotensin-converting enzyme inhibitors and coronary heart disease prevention. | Donnelly, R. and Manning, G. 2007. J Renin Angiotensin Aldosterone Syst. 8: 13-22. PMID: 17487822
- Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension. | Gojanovic, B., et al. 2008. J Renin Angiotensin Aldosterone Syst. 9: 1-9. PMID: 18404602
- Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agents. | De la Iglesia Iñigo, S., et al. 2009. Leuk Res. 33: 810-6. PMID: 19010543
- Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril. | Zhu, HJ., et al. 2009. Biochem Pharmacol. 77: 1266-72. PMID: 19185566
- Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. | Tan, X., et al. 2009. Kidney Int. 76: 1248-57. PMID: 19759524
- Angiotensin-converting enzyme inhibition, anti-hypertensive activity and hemodynamic profile of trandolapril (RU 44570). | Brown, NL., et al. 1988. Eur J Pharmacol. 148: 79-91. PMID: 3383998
- Trandolapril. How does it differ from other angiotensin converting enzyme inhibitors? | Zannad, F. 1993. Drugs. 46 Suppl 2: 172-81; discussion 182. PMID: 7512472
- Trandolapril decreases prevalence of ventricular ectopic activity in middle-aged SHR. | Chevalier, B., et al. 1995. Circulation. 92: 1947-53. PMID: 7545556
- Trandolapril's protective effects in stroke-prone spontaneously hypertensive rats persist long after treatment withdrawal. | Richer, C., et al. 1994. Am J Cardiol. 73: 26C-35C. PMID: 8166051
- Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle. | Jacob, S., et al. 1996. Metabolism. 45: 535-41. PMID: 8622594
- Vascular affinity of trandolapril. | Miyazaki, M., et al. 1995. Am J Hypertens. 8: 63S-67S. PMID: 8845086
- Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders. | Peters, DC., et al. 1998. Drugs. 56: 871-93. PMID: 9829159
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trandolapril, 10 mg | sc-203299 | 10 mg | $105.00 | |||
Trandolapril, 50 mg | sc-203299A | 50 mg | $420.00 |