Molecular structure of Tramiprosate, CAS Number: 3687-18-1
Tramiprosate (CAS 3687-18-1)
Alternate Names:
Homotaurine
Application:
Tramiprosate is a sulfated glycosaminoglycan mimic that targets amyloid β
CAS Number:
3687-18-1
Purity:
≥99%
Molecular Weight:
139.17
Molecular Formula:
C3H9NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble beta-Amyloid (amyloid beta, Abeta) and maintains beta-Amyloid (Abeta) in a non-fibrillar form. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Decreases beta-Amyloid (Abeta) 42-induced neuronal death and inhibits amyloid deposition in vitro.
Tramiprosate (CAS 3687-18-1) References
- Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. | Gervais, F., et al. 2007. Neurobiol Aging. 28: 537-47. PMID: 16675063
- Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. | Santa-Maria, I., et al. 2007. Mol Neurodegener. 2: 17. PMID: 17822548
- Reversed-phase liquid chromatographic determination of tramiprosate in rat plasma using evaporative light scattering detector. | Rao, RN., et al. 2011. Biomed Chromatogr. 25: 925-9. PMID: 21154641
- Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). | Aisen, PS., et al. 2011. Arch Med Sci. 7: 102-11. PMID: 22291741
- The potential protective effect of tramiprosate (homotaurine) against Alzheimer's disease: a review. | Caltagirone, C., et al. 2012. Aging Clin Exp Res. 24: 580-7. PMID: 22961121
- Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. | Wu, S., et al. 2014. Neuropharmacology. 83: 107-17. PMID: 24769446
- Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data. | Kocis, P., et al. 2017. CNS Drugs. 31: 495-509. PMID: 28435985
- Clinical Effects of Oral Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification. | Sabbagh, MN. 2017. J Prev Alzheimers Dis. 4: 136-137. PMID: 29182703
- Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The 'APOE4 Gene-Dose Effect'. | Abushakra, S., et al. 2016. J Prev Alzheimers Dis. 3: 219-228. PMID: 29199323
- Synergistic Inhibitory Effect of GQDs-Tramiprosate Covalent Binding on Amyloid Aggregation. | Liu, Y., et al. 2018. ACS Chem Neurosci. 9: 817-823. PMID: 29244487
- Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives. | Chakravarty, H., et al. 2020. Drug Dev Res. 81: 242-255. PMID: 31837041
- A Review on Tramiprosate (Homotaurine) in Alzheimer's Disease and Other Neurocognitive Disorders. | Manzano, S., et al. 2020. Front Neurol. 11: 614. PMID: 32733362
- Nutritional Supplements and Neuroprotective Diets and Their Potential Clinical Significance in Post-Stroke Rehabilitation. | Zielińska-Nowak, E., et al. 2021. Nutrients. 13: PMID: 34444864
Inhibitor of:
beta-Amyloid.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tramiprosate, 50 mg | sc-204353 | 50 mg | $38.00 |