TPIP Antibody (978CT6.1.4): sc-517368

TPIP Antibody (978CT6.1.4) is a mouse monoclonal IgG2a antibody that detects TPIP protein of mouse, rat, and human origin by western blotting (WB). Anti-TPIP antibody (978CT6.1.4) is available as a non-conjugated monoclonal isotype antibody. TPIP, also known as TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2), plays a crucial role in cellular signaling by regulating levels of phosphatidylinositol-3,4,5-trisphosphate, a key lipid involved in various cellular processes such as cell growth, survival, and metabolism. TPIP is primarily localized to the endoplasmic reticulum membrane, where TPIP functions as a multi-pass membrane protein with a C2 tensin-type domain and a phosphatase tensin-type domain. This localization enables TPIP to interact with other membrane-associated proteins and participate in signaling pathways vital for maintaining cellular homeostasis. TPIP exists in four alternatively spliced isoforms, with TPIP-alpha being expressed in the testis, brain, and stomach, while TPIP-beta, which lacks a transmembrane domain, is testis-specific and localizes to the cytoplasm. TPIP gene is located on human chromosome 13q12.11, highlighting evolutionary conservation and importance across species.

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TPIP Antibody (978CT6.1.4) References:

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