Molecular structure of TPBM, CAS Number: 6466-43-9
TPBM (CAS 6466-43-9)
Alternate Names:
Theophylline, 8-[(benzylthio)methyl]
Application:
TPBM is a potent inhibitor of estrogen receptor α
CAS Number:
6466-43-9
Purity:
≥97%
Molecular Weight:
316.38
Molecular Formula:
C15H16N4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An effective inhibitor of the alpha estrogen receptor via blockage of the ER-alpha dinging to consensus estrogen response element DNA. Displays minimal cellular toxicity and no effect on estrogen-independent cell growth.
TPBM (CAS 6466-43-9) References
- A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. | Mao, C., et al. 2008. J Biol Chem. 283: 12819-30. PMID: 18337247
- Modulation of nuclear receptor function: Targeting the protein-DNA interface. | Veras Ribeiro Filho, H., et al. 2019. Mol Cell Endocrinol. 484: 1-14. PMID: 30703486
- 17-β-Estradiol increases macrophage activity through activation of the G-protein-coupled estrogen receptor and improves the response of female mice to Cryptococcus gattii. | Costa, MC., et al. 2020. Cell Microbiol. 22: e13179. PMID: 32017324
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TPBM, 5 mg | sc-272620 | 5 mg | $196.00 |