Molecular structure of Toyocamycin, CAS Number: 606-58-6
Toyocamycin (CAS 606-58-6)
Alternate Names:
4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Application:
Toyocamycin is an antimetabolite with a broad spectrum of antibiotic activity
CAS Number:
606-58-6
Molecular Weight:
291.26
Molecular Formula:
C12H13N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Toyocamycin is a nucleoside antibiotic that functions as an inhibitor of RNA synthesis. It exerts its mechanism of action by specifically targeting and inhibiting the enzyme RNA polymerase. This inhibition prevents the transcription of RNA from DNA, ultimately disrupting the process of protein synthesis. Toyocamycin achieves this by binding to the active site of RNA polymerase, thereby interfering with the enzyme′s ability to catalyze the formation of RNA molecules. This disruption of RNA synthesis can have significant implications for the study of gene expression and regulation in experimental applications.
Toyocamycin (CAS 606-58-6) References
- Toyocamycin specifically inhibits auxin signaling mediated by SCFTIR1 pathway. | Hayashi, K., et al. 2009. Phytochemistry. 70: 190-7. PMID: 19171357
- A toyocamycin analogue with the sugar moiety in a syn conformation. | Seela, F., et al. 2009. Acta Crystallogr C. 65: o431-4. PMID: 19726854
- Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity. | Kiburu, IN. and LaRonde-LeBlanc, N. 2012. PLoS One. 7: e37371. PMID: 22629386
- Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. | Ri, M., et al. 2012. Blood Cancer J. 2: e79. PMID: 22852048
- Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells. | Park, SG., et al. 2017. Pharmacol Rep. 69: 90-96. PMID: 27912102
- Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. | Takahara, I., et al. 2017. PLoS One. 12: e0170591. PMID: 28278289
- Substantial improvement of toyocamycin production in Streptomyces diastatochromogenes by cumulative drug-resistance mutations. | Shentu, XP., et al. 2018. PLoS One. 13: e0203006. PMID: 30161195
- Cloning and Overexpression of the Toy Cluster for Titer Improvement of Toyocamycin in Streptomyces diastatochromogenes. | Ma, Z., et al. 2020. Front Microbiol. 11: 2074. PMID: 32983052
- Enhancement of toyocamycin production through increasing supply of precursor GTP in Streptomyces diastatochromogenes 1628. | Zhang, J., et al. 2022. J Basic Microbiol. 62: 750-759. PMID: 35076122
- Effect of toyF on wuyiencin and toyocamycin production by Streptomyces albulus CK-15. | Liu, B., et al. 2022. World J Microbiol Biotechnol. 38: 65. PMID: 35229201
- RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2. | Chen, Y., et al. 2022. Oncogene. 41: 3433-3444. PMID: 35589951
- Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells. | Pandey, S., et al. 2022. Cancers (Basel). 14: PMID: 35884401
- Concentrative Nucleoside Transporter, CNT, Results in Selective Toxicity of Toyocamycin against Candida albicans. | Ojima, Y., et al. 2022. Microbiol Spectr. 10: e0113822. PMID: 35913167
- Chemotherapy Mediated by Biomimetic Polymeric Nanoparticles Potentiates Enhanced Tumor Immunotherapy via Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. | Guo, Y., et al. 2022. Adv Mater. 34: e2206861. PMID: 36125843
Inhibitor of:
AK8, CELF6, CGI-99_2700060E02Rik, CROP, DDX17, HMBOX1, Nop10, NXF7, PI 3-kinase, RBM12B, Rpp30, SDCCAG10, Sm D2, U11/U12 snRNP 25, U2 snRNP A, UCK1, XBP-1, ZCCHC11, ZCCHC4, and ZFR2.Activator of:
LSm11, and SURF-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Toyocamycin, 10 mg | sc-362812 | 10 mg | $138.00 |