Toxin A from Clostridium difficile
Application:
Toxin A from Clostridium difficile is a high molecular weight, small molecule GTPase inhibitor
Molecular Weight:
~270000
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Toxin A, Clostridium difficileD is a high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositol 4,5-bisphosphate. This toxin does not require assistance to permeabilize cells, unlike Exoenzyme C3 . It also binds to fresh rabbit red blood cells in a hemagglutination assay, and is cytotoxic as determined by a cell rounding assay using human foreskin cells.
Toxin A from Clostridium difficile References
- Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. | Mahida, YR., et al. 1996. Gut. 38: 337-47. PMID: 8675084
- Clostridium difficile toxins attack Rho. | Wilkins, TD. and Lyerly, DM. 1996. Trends Microbiol. 4: 49-51. PMID: 8820565
- Rho GTPases. | Mackay, DJ. and Hall, A. 1998. J Biol Chem. 273: 20685-8. PMID: 9694808
Inhibitor of:
Cdc42, Rac, and Rhodopsin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Toxin A from Clostridium difficile, 2 µg | sc-222361 | 2 µg | $196.00 | |||
Toxin A from Clostridium difficile, 100 µg | sc-222361A | 100 µg | $787.00 |