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Tosufloxacin tosylate (CAS 115964-29-9)

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Alternate Names:
7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid tosylate; A-64730
Application:
Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor
CAS Number:
115964-29-9
Purity:
≥98%
Molecular Weight:
576.55
Molecular Formula:
C19H15F3N4O3•C7H8O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tosufloxacin tosylate is a fluoroquinolone antibacterial agent. Tosufloxacin tosylate is also a bacterial Topo (DNA gyrase, topoisomerase)) inhibitor. Tosufloxacin tosylate is effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.


Tosufloxacin tosylate (CAS 115964-29-9) References

  1. [In vitro bactericidal effect of temafloxacin and tosufloxacin against streptococci].  |  Aubert, G., et al. 1991. Pathol Biol (Paris). 39: 1002-5. PMID: 1666667
  2. Comparison of moxifloxacin and levofloxacin in an epithelial disorder model using cultured rabbit corneal epithelial cell sheets.  |  Miyake, T., et al. 2012. Graefes Arch Clin Exp Ophthalmol. 250: 1035-41. PMID: 22282216
  3. [Mn2+-cTMAB-sensitized fluorescent microscopic determination of tosufloxacin tosylate based on a self-ordered ring].  |  Deng, FY., et al. 2014. Guang Pu Xue Yu Guang Pu Fen Xi. 34: 445-9. PMID: 24822418
  4. Tosufloxacin deposits in compromised corneas.  |  Kim, YD., et al. 2014. Optom Vis Sci. 91: e241-4. PMID: 25036547
  5. Probing the interaction of cefodizime with human serum albumin using multi-spectroscopic and molecular docking techniques.  |  Hu, T. and Liu, Y. 2015. J Pharm Biomed Anal. 107: 325-32. PMID: 25637820
  6. Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan.  |  Theis, T., et al. 2018. Mol Neurobiol. 55: 8203-8215. PMID: 29520715
  7. Comprehensive screening of antimicrobials to control phytoplasma diseases using an in vitro plant-phytoplasma co-culture system.  |  Tanno, K., et al. 2018. Microbiology (Reading). 164: 1048-1058. PMID: 29952745
  8. Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS.  |  Jin, B., et al. 2019. J Anal Methods Chem. 2019: 4059765. PMID: 31687249
  9. Effect of xanthan gum-based food thickeners on the dissolution profile of fluoroquinolones oral formulations.  |  Takahashi, N., et al. 2020. J Pharm Health Care Sci. 6: 25. PMID: 33292643
  10. Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer.  |  Okamoto, N., et al. 2024. Pharm Res. 41: 959-966. PMID: 38653942

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tosufloxacin tosylate, 250 mg

sc-204920
250 mg
$98.00

Tosufloxacin tosylate, 1 g

sc-204920A
1 g
$294.00

Do you have data on the water content of this compound tosufloxacin tosylate?

Asked by: T Muratani
Thank you for your question.Please contact our Technical Service Department of Japan for more information. https://www.scbt.com/ja/resources/distributors?&_requestid=1655
Answered by: Jiajun Z
Date published: 2023-11-10
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Rated 5 out of 5 by from LewisX mimeticGlycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX. Theis et al. (PMID 29520715)identified Tosufloxacin tosylate as one LewisX mimetic.
Date published: 2019-05-14
Rated 5 out of 5 by from DengDeng, FY. et al. (PubMed 24822418) reported that with poly (vinyl alcohol)-124 (PVA-124) and NH3-NH4Cl (pH 10.50) as the medium, Mn2+ and cetyltrimethyl ammonium bromide (CTMAB) as sensitizer, Tosufloxacin tosylate (TSFX) formed a self-ordered ring (SOR) on a hydrophobic glass slide support. -SCBT Publication Review
Date published: 2015-03-20
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Tosufloxacin tosylate is rated 5.0 out of 5 by 2.
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